Pleiotropic Genes Affecting Carcass Traits in Bos indicus (Nellore) Cattle Are Modulators of Growth

Autor(es):Mostrar menos -

Pereira, Anirene G. T. ^{[1, 2]} ; Utsunomiya, Yuri T. ^{[3, 2]} ; Milanesi, Marco ^{[2, 4]} ; Torrecilha, Rafaela B. P. ^{[3, 2]} ; Carmo, Adriana S. ^{[3, 2]} ; Neves, Haroldo H. R. ^[5] ; Carvalheiro, Roberto ^[6] ; Ajmone-Marsan, Paolo ^[7] ; Sonstegard, Tad S. ^[8] ; Solkner, Johann ^[9] ; Contreras-Castillo, Carmen J. ^[1] ; Garcia, Jose F. ^{[3, 2, 4]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Escola Super Agr Luiz de Queiroz, Dept Agroind Alimentos & Nutr, Piracicaba - Brazil

^[2] IAEA, Collaborating Ctr Anim Genom & Bioinformat, Aracatuba, SP - Brazil

^[3] UNESP Univ Estadual Paulista, Dept Med Vet Prevent & Reprod Anim, Fac Ciencias Agr & Vet, Jaboticabal, SP - Brazil

^[4] UNESP Univ Estadual Paulista, Dept Apoio Prod & Saude Anim, Fac Med Vet & Aracatuba, Aracatuba, SP - Brazil

^[5] GenSys Consultores Assoc, Porto Alegre, RS - Brazil

^[6] UNESP Univ Estadual Paulista, Dept Zootecnia, Fac Ciencias Agr & Vet, Jaboticabal, SP - Brazil

^[7] Univ Cattolica Sacro Cuore, Piacenza - Italy

^[8] Recombinetics Inc, St Paul, MN - USA

^[9] BOKU Univ Nat Resources & Life Sci, Dept Sustainable Agr Syst, Div Livestock Sci, Vienna - Austria

• Tipo de documento: Artigo Científico
• Fonte: PLoS One; v. 11, n. 7 JUL 13 2016.
• Citações Web of Science: 5

Resumo

Two complementary methods, namely Multi-Trait Meta-Analysis and Versatile Gene-Based Test for Genome-wide Association Studies (VEGAS), were used to identify putative pleiotropic genes affecting carcass traits in Bos indicus (Nellore) cattle. The genotypic data comprised over 777,000 single-nucleotide polymorphism markers scored in 995 bulls, and the phenotypic data included deregressed breeding values (dEBV) for weight measurements at birth, weaning and yearling, as well visual scores taken at weaning and yearling for carcass finishing precocity, conformation and muscling. Both analyses pointed to the pleomorphic adenoma gene 1 (PLAG1) as a major pleiotropic gene. VEGAS analysis revealed 224 additional candidates. From these, 57 participated, together with PLAG1, in a network involved in the modulation of the function and expression of IGF1 (insulin like growth factor 1), IGF2 (insulin like growth factor 2), GH1 (growth hormone 1), IGF1R (insulin like growth factor 1 receptor) and GHR (growth hormone receptor), suggesting that those pleiotropic genes operate as satellite regulators of the growth pathway. (AU)

• Processo FAPESP: 14/01095-8 - Utilização de sequenciamento de nova geração para o mapeamento fino de regiões cromossômicas que afetam o perímetro escrotal de touros Nelore
• Beneficiário: Yuri Tani Utsunomiya
• Linha de fomento: Bolsas no Brasil - Doutorado
• Processo FAPESP: 13/02552-0 - Estudo de associação genômica em bovinos da raça Nelore para características quantitativas e qualitativas de carcaça e carne
• Beneficiário: Anirene Galvão Tavares Pereira
• Linha de fomento: Bolsas no Brasil - Doutorado