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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Influence of apoptosis on liver and spleen resistance in dogs with visceral leishmaniosis

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Autor(es):
Reina Moreira, Pamela Rodrigues ; Franciscato, Douglas Augusto ; Rossit, Sabrina Micelli ; Munari, Danisio Prado ; Vasconcelos, Rosemeri de Oliveira
Número total de Autores: 5
Tipo de documento: Artigo Científico
Fonte: Revista Brasileira de Parasitologia Veterinária; v. 25, n. 3, p. 341-347, JUL-SEP 2016.
Citações Web of Science: 2
Resumo

The aim of this study was to evaluate apoptosis and parasite load in the liver and spleen of dogs with visceral leishmaniosis (VL), using immunohistochemistry. Liver and spleen samples from 71 dogs with VL were used. The parasite load in the spleen and liver showed significant difference between organs in infected group (P=0.0219). The density of the parasite load in the spleen (median=2.4) was higher than liver (median=0.8). Immunodetection of apoptotic cells was predominant in lymphocytes and differ between the infected and control group in spleen (P=0.0307) and liver (P=0.0346). There was a significant correlation between apoptosis and parasite load (P=0.0084; r=0.3104) only in the spleen of the infected group, where it was observed that, when increasing the number of apoptotic cells increases the parasitic load. It was concluded that the liver and spleen of infected dogs presented greater numbers of cells undergoing apoptosis (lymphocytes) than the control group, thus suggesting that this process may be contributing towards the survival of Leishmania in these organs, because lymphocyte in apoptosis did not have the ability to present and recognize the antigen, allowing the survival of the parasite. (AU)

Processo FAPESP: 09/15736-7 - Participação das células natural killer hepáticas (PIT) no fígado de cães com leishmaniose visceral
Beneficiário:Pamela Rodrigues Reina Moreira
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 09/07815-4 - Avaliação da expressão de MIF,iNOS e MHC-II em macrófagos de linfonodos de cães com leishmaniose visceral
Beneficiário:Rosemeri de Oliveira Vasconcelos
Linha de fomento: Auxílio à Pesquisa - Regular