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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Associations of Blood Pressure with Functional and Cognitive Changes in Patients with Alzheimer's Disease

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Autor(es):
de Oliveira, Fabricio Ferreira ; Chen, Elizabeth Suchi ; Smith, Marilia Cardoso ; Ferreira Bertolucci, Paulo Henrique
Número total de Autores: 4
Tipo de documento: Artigo Científico
Fonte: DEMENTIA AND GERIATRIC COGNITIVE DISORDERS; v. 41, n. 5-6, p. 314-323, 2016.
Citações Web of Science: 8
Resumo

Background: Midlife hypertension followed by late life hypotension resulting from neurodegeneration increases amyloidogenesis and tauopathy. Methods: Consecutive outpatients with late-onset Alzheimer's disease (AD) at various stages and their respective caregivers were assessed for score variations in 1 year of tests assessing caregiver burden, functionality and cognition according to blood pressure (BP) variations and APOE haplotypes, while also taking into account differential effects of angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, beta-blockers, calcium channel blockers, diuretics, or no antihypertensive medication on score changes. The diagnosis and treatment of arterial hypertension followed the JNC 7 report. Results: Variations in systolic BP (-11.76 +/- 17.1 mm Hg), diastolic BP (-4.92 +/- 10.3 mm Hg) and pulse pressure (-6.84 +/- 12.6 mm Hg) were significant after 1 year (n = 191;. < 0.01). For APOE4+ carriers, rises in systolic or diastolic BP improved Clinical Dementia Rating Scale Sum of Boxes scores (rho < 0.04), with marginally significant improvements in MiniMental State Examination scores resulting from risen systolic (rho = 0.069) or diastolic BP (. = 0.079), and in basic independence only regarding risen diastolic BP (rho = 0.055). APOE4-carriers resisted any functional or cognitive effects of BP variations. No differences were found regarding any antihypertensive class for variations in BP or any test scores, regardless of APOE haplotypes. Conclusions: Targeting mild BP elevations brings better functional and cognitive results for APOE4+ carriers with AD. (C) 2016 S. Karger AG, Basel (AU)

Processo FAPESP: 15/10109-5 - Análise comparativa de marcadores liquóricos e séricos na demência com corpúsculos de Lewy e na demência da Doença de Alzheimer
Beneficiário:Fabricio Ferreira de Oliveira
Linha de fomento: Bolsas no Brasil - Pós-Doutorado