Serotoninergic antidepressants positively affect platelet ADAM10 expression in patients with Alzheimer's disease

Autor(es)

Fernandes Marques Bianco, Otavio Augusto ; Manzine, Patricia Regina ; Crispim Nascimento, Carla Manuela ; Carvalho Vale, Francisco Assis ; Iost Pavarini, Sofia Cristina ; Cominetti, Marcia Regina

• Tipo de documento: Artigo Científico
• Fonte: INTERNATIONAL PSYCHOGERIATRICS; v. 28, n. 6, p. 939-944, JUN 2016.
• Citações Web of Science: 5

Resumo

Background: Studies have demonstrated a decreased platelet ADAM10 expression in patients with Alzheimer's Disease (AD), classifying this protein as a blood-based AD biomarker. About 50% of the patients with AD are diagnosed with depression, which is commonly treated with tricyclic and tetracyclic antidepressants, monoaminoxidade (MAO) inhibitors and, more preferably, with selective serotonin reuptake inhibitors (SSRIs). Considering that a large proportion of patients with AD takes antidepressant medications during the course of the disease we investigated the influence of this medication on the expression of platelet ADAM10, which is considered the main alpha-secretase preventing beta-amyloid (beta A) formation. Methods: Blood was collected for protein extraction from platelets. ADAM10 was analyzed by using western blotting and reactive bands were measured using beta-actin as endogenous control. Results: Platelet ADAM10 protein expression in patients with AD was positively influenced by serotoninergic medication. Conclusion: More studies on the positive effects of serotonergic antidepressants on ADAM10 platelet expression should be performed in order to understand its biological mechanisms and to verify whether these effects are reflected in the central nervous system. This work represents an important advance for the study of AD biomarkers, as well as for more effective pharmacological treatment of patients with AD and associated depression. (AU)

• Processo FAPESP: 10/09497-7 - Níveis plaquetários da ADAM10 no rastreamento da doença de Alzheimer: contribuições para o cuidado de enfermagem
• Beneficiário: Sofia Cristina Iost Pavarini
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 12/01936-7 - Influência do uso de antidepressivos nos níveis plaquetários da ADAM10 na Doença de Alzheimer
• Beneficiário: Otávio Augusto Fernandes Marques Bianco
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 14/21066-2 - Expressão gênica de citocinas inflamatórias e de microRNAs candidatos a biomarcadores de fragilidade em idosos em contexto de vulnerabilidade social.
• Beneficiário: Carla Manuela Crispim Nascimento
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 13/06879-4 - Biomarcadores sanguíneos para a Doença de Alzheimer: avaliação da expressão gênica da ADAM10 e de microRNAs
• Beneficiário: Márcia Regina Cominetti
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 12/08654-7 - Biomarcadores sanguíneos para a Doença de Alzheimer: avaliação da expressão gênica da ADAM10 e de micro-RNAs
• Beneficiário: Patricia Regina Manzine Moralles
• Modalidade de apoio: Bolsas no Brasil - Doutorado