Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Brasiliensic and isobrasiliensic acids: isolation from Calophyllum brasiliense Cambess. and anti-Helicobacter pylori activity

Texto completo
Autor(es):
Lemos, Larissa M. S. ; Oliveira, Rejane B. ; Sampaio, Bruno L. ; Ccana-Ccapatinta, Gari V. ; Da Costa, Fernando B. ; Martins, Domingos T. O.
Número total de Autores: 6
Tipo de documento: Artigo Científico
Fonte: NATURAL PRODUCT RESEARCH; v. 30, n. 23, p. 2720-2725, 2016.
Citações Web of Science: 4
Resumo

The occurrence of chromanone derivatives has been noticed as a distinctive feature of the genus Calophyllum (Calophyllaceae). Previous studies have demonstrated that the extract of the stem bark of Calophyllum brasiliense and its chromanone-rich fractions show anti-ulcer activity in murine gastric ulcer models. In this work, brasiliensic and isobrasiliensic acids, the two main compounds of the n-hexane extract of the stem bark extract of C. brasiliense, were isolated by flash chromatography using silica gel impregnated with silver nitrate and their structures were elucidated by NMR techniques and mass spectrometry. C-13 NMR data is available for the first time for both compounds. Brasiliensic and isobrasiliensic acids showed good in vitro bacteriostatic activity against Helicobacter pylori, and are responsible, at least in part, for the bacteriostatic anti-H. pylori activity of the n-hexane extract of the stem bark of C. brasiliense. {[}GRAPHICS] . (AU)

Processo FAPESP: 08/57149-8 - Potencial químico e farmacológico de espécies da familia Asteraceae: estudos integrados in vivo, in vitro e in silico
Beneficiário:Fernando Batista da Costa
Linha de fomento: Auxílio à Pesquisa - Regular