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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Local antibiotic delivery in periodontitis: drug release and its effect on supragingival biofilms

Texto completo
Autor(es):
Re, A. C. S. ; Ferreira, M. P. ; Freitas, O. ; Aires, C. P.
Número total de Autores: 4
Tipo de documento: Artigo Científico
Fonte: BIOFOULING; v. 32, n. 9, p. 1061-1066, 2016.
Citações Web of Science: 4
Resumo

The effect of a drug-delivery system containing antibacterial metronidazole (MDZ) prescribed for periodontitis on supragingival biofilm was evaluated, and possible interference by this biofilm in the drug release profile was investigated. Streptococcus mutans biofilms were grown and exposed to a controlled-release formulation of MDZ or the same formulation without MDZ (vehicle control). Untreated biofilms were used as a negative control (NC). Biofilms and culture medium (containing detached cells) were collected 24, 48, 72, and 96 h after first exposure to treatments. The biomass of the MDZ group was lower than that of the NC group at all times. Although MDZ yielded low drug-release rates in the presence of the biofilm, it was sufficient for reducing viability for 24 h and affecting bacterial metabolism for 48 h. These results suggest that MDZ appears to destabilize supragingival biofilm. This biofilm may interfere with MDZ release from the formulation. (AU)

Processo FAPESP: 12/15556-1 - Adequação e efeito de um Sistema de Liberação Sustentada de Fármaco na Presença de Biofilme Patogênico
Beneficiário:Ana Carolina dos Santos Ré
Linha de fomento: Bolsas no Brasil - Iniciação Científica
Processo FAPESP: 12/15423-1 - Adequação e efeito de um sistema de liberação sustentada de fármaco na presença de biofilme patogênico
Beneficiário:Carolina Patrícia Aires
Linha de fomento: Auxílio à Pesquisa - Regular