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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Behavioral and neuroimaging responses induced by mental imagery of threatening scenarios

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Autor(es):
Shuhama, Rosana ; Rondinoni, Carlo ; de Araujo, Draulio Barros ; Caetano, Gustavo de Freitas ; dos Santos, Antonio Carlos ; Graeff, Frederico Guilherme ; Del-Ben, Cristina Marta
Número total de Autores: 7
Tipo de documento: Artigo Científico
Fonte: Behavioural Brain Research; v. 313, p. 358-369, OCT 15 2016.
Citações Web of Science: 7
Resumo

Functional neuroimaging studies have shown that actual situations of uncertain or distant threats increase the activity of forebrain regions, whereas proximal threats increase the activity of the dorsal midbrain. This experiment aimed at testing the hypothesis that brain activity elicited by imagined scenarios of threats with two different magnitudes, potential and imminent, resembles that found in response to actual threats. First, we measured subjective responses to imagined scenarios of potential and imminent threats compared with neutral and pleasant scenarios. The same scenarios were used as a paradigm in a functional magnetic resonance imaging experiment. Behavioral results show that the scenarios draw a gradient of hedonic valence and arousal dimensions. Both potential and imminent threat scenarios increased subjective anxiety; the imminent threat scenario also increased feelings of discomfort and bodily symptoms. The functional magnetic resonance imaging results revealed modulations of BOLD signal in the ventromedial prefrontal cortex by potential threat and in the periaqueductal gray matter by imminent threat. These results agree with previously reported evidence using actual threat situations, indicating that mental imagery is a reliable method for studying the functional neuroanatomy of relevant behavioral processes. (C) 2016 Elsevier B.V. All rights reserved. (AU)

Processo FAPESP: 07/03685-3 - Neurotransmissores típicos e atípicos em transtornos neuropsiquiátricos
Beneficiário:Francisco Silveira Guimaraes
Linha de fomento: Auxílio à Pesquisa - Temático