| Texto completo | |
| Autor(es): |
Bauermeister, Anelize
;
Aguiar, Fernando Armani
;
Mauriz Marques, Lucas Maciel
;
Malta, Jr., Jose Dos Santos
;
Barros, Fabio
;
Callejon, Daniel Roberto
;
Moraes de Oliveira, Anderson Rodrigo
;
Lopes, Norberto Peporine
Número total de Autores: 8
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Planta Medica; v. 82, n. 15, p. 1368-1373, OCT 2016. |
| Citações Web of Science: | 2 |
| Resumo | |
Dihydroergotamine is a semisynthetic natural product derived from ergotamine, an ergot alkaloid. It is used to treat migraines, a neurological disease characterized by recurrent moderate to severe headaches. In this work, the in vitro metabolism of dihydroergotamine was evaluated in a biomimetic phase I reaction, aiming to verify all possible formed metabolites. Dihydroergotamine was submitted to an in vitro metabolism assay using rat liver microsomes, and the metabolites were analyzed by HPLC-MS/MS. The biomimetic reactions were performed with Jacobsen catalyst for scaling up production of oxidized metabolites. Two hydroxylated metabolites were isolated and characterized by MS/MS and H-1 NMR analysis. (AU) | |
| Processo FAPESP: | 13/16496-5 - Avaliação do metabolismo in vitro, in vivo e do perfil farmacocinético do alcalóide govaniadina |
| Beneficiário: | Lucas Maciel Mauriz Marques |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 14/50265-3 - Metabolismo e distribuição de xenobióticos naturais e sintéticos: da compreensão dos processos reacionais à geração de imagens teciduais |
| Beneficiário: | Norberto Peporine Lopes |
| Modalidade de apoio: | Auxílio à Pesquisa - Programa BIOTA - Temático |