| Texto completo | |
| Autor(es): |
de Araujo, Gabriel L. B.
;
Zeller, Matthias
;
Smith, Daniel
;
Nie, Haichen
;
Byrn, Stephen R.
Número total de Autores: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Crystal Growth & Design; v. 16, n. 10, p. 6122-6130, OCT 2016. |
| Citações Web of Science: | 1 |
| Resumo | |
Single crystal growth of lapatinib free base was induced by immersion of a copper wire into a supersaturated methanolic aqueous solution yielding monoclinic anhydrous plates (space group P2(1)/c, Form 1) and needles of a previously unknown channel hydrate (in P4(2)2(1)/2). Also, a new method has been developed herein to obtain anhydrous Form 1 via acid base reaction of lapatinib ditosylate and sodium methoxide, avoiding the usage of an aqueous solution and hydrate formation. Anhydrous Form 2 as well as new solvates were produced via solution mediated transformation experiments, including a dichloromethane solvate with a powder X-ray diffraction pattern similar to that of anhydrous Form 2. Differential scanning calorimetry and solution equilibrium experiments helped to elucidate the interconversion pathways between Form 1, Form 2, and the solvates. (AU) | |
| Processo FAPESP: | 15/15456-5 - Estudo do polimorfismo de pequenas moléculas inibidoras da tirosina quinase. |
| Beneficiário: | Gabriel Lima Barros de Araujo |
| Modalidade de apoio: | Bolsas no Exterior - Pesquisa |
| Processo FAPESP: | 15/05685-7 - Cristalização e polimorfismo do Flubendazol e outros fármacos mal caracterizados |
| Beneficiário: | Gabriel Lima Barros de Araujo |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |