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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Colubrid Venom Composition: An -Omics Perspective

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Autor(es):
Junqueira-de-Azevedo, Inacio L. M. ; Campos, Pollyanna F. ; Ching, Ana T. C. ; Mackessy, Stephen P.
Número total de Autores: 4
Tipo de documento: Artigo de Revisão
Fonte: TOXINS; v. 8, n. 8 AUG 2016.
Citações Web of Science: 27
Resumo

Snake venoms have been subjected to increasingly sensitive analyses for well over 100 years, but most research has been restricted to front-fanged snakes, which actually represent a relatively small proportion of extant species of advanced snakes. Because rear-fanged snakes are a diverse and distinct radiation of the advanced snakes, understanding venom composition among ``colubrids{''} is critical to understanding the evolution of venom among snakes. Here we review the state of knowledge concerning rear-fanged snake venom composition, emphasizing those toxins for which protein or transcript sequences are available. We have also added new transcriptome-based data on venoms of three species of rear-fanged snakes. Based on this compilation, it is apparent that several components, including cysteine-rich secretory proteins (CRiSPs), C-type lectins (CTLs), CTLs-like proteins and snake venom metalloproteinases (SVMPs), are broadly distributed among ``colubrid{''} venoms, while others, notably three-finger toxins (3FTxs), appear nearly restricted to the Colubridae (sensu stricto). Some putative new toxins, such as snake venom matrix metalloproteinases, are in fact present in several colubrid venoms, while others are only transcribed, at lower levels. This work provides insights into the evolution of these toxin classes, but because only a small number of species have been explored, generalizations are still rather limited. It is likely that new venom protein families await discovery, particularly among those species with highly specialized diets. (AU)

Processo FAPESP: 13/07467-1 - CeTICS - Centro de Toxinas, Imuno-Resposta e Sinalização Celular
Beneficiário:Hugo Aguirre Armelin
Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
Processo FAPESP: 12/00177-5 - Sequenciamento do genoma da serpente Bothrops jararaca para caracterização da estrutura gênica de toxinas e seus elementos regulatórios
Beneficiário:Inácio de Loiola Meirelles Junqueira de Azevedo
Linha de fomento: Auxílio à Pesquisa - Regular