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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

The Expression of the Androgen Receptor and Estrogen Receptor 1 is Related to Sex Dimorphism in the Gerbil Prostate Development

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Autor(es):
Sanches, Bruno D. A. ; Maldarine, Juliana S. ; Zani, Bruno C. ; Biancardi, Manoel F. ; Santos, Fernanda C. A. ; Goes, Rejane M. ; Vilamaior, Patricia S. L. ; Taboga, Sebastiao R.
Número total de Autores: 8
Tipo de documento: Artigo Científico
Fonte: Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology; v. 299, n. 8, p. 1130-1139, AUG 2016.
Citações Web of Science: 2
Resumo

The development of the prostate gland in females has not yet been clearly elucidated, and the sexual dimorphism associated with such gland development in general is far from being understood. In the present study, we used tridimensional (3D) reconstructions and histochemical and immunohistochemical techniques to describe the sexual dimorphism and its causes in the early postnatal development of the prostate in male and female Mongolian gerbils (Meriones unguiculatus). We observed that the female prostate was smaller, had fewer branches throughout the development, and underwent differentiation earlier than that in males. Also, the expression of the estrogen receptor 1 (ESR1 or ER-alpha) and fibroblast growth factor 10 (FGF10) was decreased in the periductal region, and the expression of the androgen receptor (AR) was increased in the epithelium. All together, these changes decreased proliferation and branching and led to an earlier prematuration of the female prostate. These new data shed light on the underlying mechanisms involved with the sexual dimorphism in the development of the prostate. Anat Rec, 299:1130-1139, 2016. (C) 2016 Wiley Periodicals, Inc. (AU)

Processo FAPESP: 13/16443-9 - Estudo descritivo do processo de ramificação do lobo ventral da próstata do Gerbilo da Mongólia (Meriones Unguiculatus)
Beneficiário:Bruno Casagrande Zani
Linha de fomento: Bolsas no Brasil - Iniciação Científica
Processo FAPESP: 13/15939-0 - Avaliação da exposição estrogênica intra-uterina sobre as principais vias de interações epitélio-mesenquimais envolvidas na morfogênese das ramificações do lobo ventral da próstata do Gerbilo da Mongólia (Meriones unguiculatus)
Beneficiário:Bruno Domingos Azevedo Sanches
Linha de fomento: Bolsas no Brasil - Doutorado Direto