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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Deep Brain Stimulation: More Complex than the Inhibition of Cells and Excitation of Fibers

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Autor(es):
Florence, Gerson ; Sameshima, Koichi ; Fonoff, Erich T. ; Hamani, Clement
Número total de Autores: 4
Tipo de documento: Artigo Científico
Fonte: NEUROSCIENTIST; v. 22, n. 4, p. 332-345, AUG 2016.
Citações Web of Science: 23
Resumo

High-frequency deep brain stimulation (DBS) is an effective treatment for some movement disorders. Though mechanisms underlying DBS are still unclear, commonly accepted theories include a functional inhibition of neuronal cell bodies and the excitation of axonal projections near the electrodes. It is becoming clear, however, that the paradoxical dissociation local inhibition and distant excitation is far more complex than initially thought. Despite an initial increase in neuronal activity following stimulation, cells are often unable to maintain normal ionic concentrations, particularly those of sodium and potassium. Based on currently available evidence, we proposed an alternative hypothesis. Increased extracellular concentrations of potassium during DBS may change the dynamics of both cells and axons, contributing not only to the intermittent excitation and inhibition of these elements but also to interrupt abnormal pathological activity. In this article, we review mechanisms through which high extracellular potassium may mediate some of the effects of DBS. (AU)

Processo FAPESP: 11/08529-5 - Estudo controlado e duplamente encoberto sobre o efeito do ozônio aplicado por endoscopia espinhal no tratamento da síndrome dolorosa pós-laminectomia: análise na dor neuropática e não neuropática e sua correlação com o nível de citocinas epidurais
Beneficiário:Erich Talamoni Fonoff
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 11/21138-5 - Análise de padrões oscilatórios de registros intracirúrgicos em estimulação cerebral profunda para Doença de Parkinson
Beneficiário:Gerson Florence Carvalheira de Azevedo
Linha de fomento: Bolsas no Brasil - Pós-Doutorado