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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

The relationship between sleep apnea, metabolic dysfunction and inflammation: The gender influence

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Autor(es):
Hirotsu, Camila ; Albuquerque, Rachel G. ; Nogueira, Heloisa ; Hachul, Helena ; Bittencourt, Lia ; Tufik, Sergio ; Andersen, Monica L.
Número total de Autores: 7
Tipo de documento: Artigo Científico
Fonte: BRAIN BEHAVIOR AND IMMUNITY; v. 59, p. 211-218, JAN 2017.
Citações Web of Science: 5
Resumo

Obstructive sleep apnea (OSA) has been associated with increased risk of cardiovascular morbidity and mortality. Although inflammatory markers may mediate this association, it is unknown the influence of gender in this mechanism. Thus, we aimed to evaluate the interaction effects between OSA and gender on metabolic and inflammatory profile in a population sample. This study is part of EPISONO cohort, in which 1042 participants underwent polysomnography, answered questionnaires, and had their blood collected for analysis of fasting glucose, total cholesterol and fractions, leptin, ghrelin, liver transaminases, tumor necrosis factor (TNE)-alpha, interleukin (IL)-6, and C-reactive protein. The results showed that men with OSA had higher leptin levels, shorter sleep latency and lower N3 sleep stage compared to men control (CTRL). They also presented higher apnea index and number of central apneas compared to both CTRL men and OSA women. In women, OSA was related to longer REM sleep latency, higher apnea-hypopnea index (AHI) during REM sleep and increased TNF-alpha levels compared to CTRL women. A multivariate model showed that male gender, ghrelin and total cholesterol were negatively associated with TNF-alpha, while IL-6, triglycerides and hypopnea index were positively associated (R-2 = 0.21). Additionally, gender (men), body mass index, ghrelin, apnea index and smoking were positive predictors of leptin levels (R-2 = 0.55). Of note, postmenopause was associated with changes observed in both TNF-alpha. and AHI during REM sleep in women with OSA. Taken together, our study suggests that OSA consequences may differ between genders and this could indicate a need for different OSA management in women according to their reproductive life's stage. (C) 2016 Elsevier Inc. All rights reserved. (AU)

Processo FAPESP: 14/27329-5 - Análise do padrão de sono e da secreção de citocinas em pacientes com hanseníase
Beneficiário:Rachel Gimenes Rodrigues Albuquerque
Linha de fomento: Bolsas no Brasil - Doutorado Direto
Processo FAPESP: 14/15259-2 - Epidemiologia do sono na Cidade de São Paulo: seguimento dos voluntários do estudo de base EPISONO
Beneficiário:Camila Hirotsu
Linha de fomento: Bolsas no Brasil - Pós-Doutorado