Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Gene expression differences in Longissimus muscle of Nelore steers genetically divergent for residual feed intake

Texto completo
Autor(es):
Mostrar menos -
Tizioto, Polyana C. ; Coutinho, Luiz L. ; Oliveira, Priscila S. N. ; Cesar, Aline S. M. ; Diniz, Wellison J. S. ; Lima, Andressa O. ; Rocha, Marina I. ; Decker, Jared E. ; Schnabel, Robert D. ; Mourao, Gerson B. ; Tullio, Rymer R. ; Zerlotini, Adhemar ; Taylor, Jeremy F. ; Regitano, Luciana C. A.
Número total de Autores: 14
Tipo de documento: Artigo Científico
Fonte: SCIENTIFIC REPORTS; v. 6, DEC 22 2016.
Citações Web of Science: 14
Resumo

Residual feed intake (RFI), a measure of feed efficiency (FE), is defined as the difference between the observed and the predictable feed intake considering size and growth of the animal. It is extremely important to beef production systems due to its impact on the allocation of land areas to alternative agricultural production, animal methane emissions, food demand and cost of production. Global differential gene expression analysis between high and low RFI groups (HRFI and LRFI: less and more efficient, respectively) revealed 73 differentially expressed (DE) annotated genes in Longissimus thoracis (LT) muscle of Nelore steers. These genes are involved in the overrepresented pathways Metabolism of Xenobiotics by Cytochrome P450 and Butanoate and Tryptophan Metabolism. Among the DE transcripts were several proteins related to mitochondrial function and the metabolism of lipids. Our findings indicate that observed gene expression differences are primarily related to metabolic processes underlying oxidative stress. Genes involved in the metabolism of xenobiotics and antioxidant mechanisms were primarily down-regulated, while genes responsible for lipid oxidation and ketogenesis were up-regulated in HRFI group. By using LT muscle, this study reinforces our previous findings using liver tissue and reveals new genes and likely tissue-specific regulators playing key-roles in these processes. (AU)

Processo FAPESP: 12/23638-8 - Bases moleculares da qualidade da carne em bovinos da raça Nelore
Beneficiário:Luciana Correia de Almeida Regitano
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 13/17778-4 - Perfil transcriptômico de animais extremos para eficiência alimentar da raça Nelore
Beneficiário:Polyana Cristine Tizioto
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 14/13555-3 - Perfil de expressão gênica de novilhos Nelore com fenótipos divergentes para consumo alimentar residual
Beneficiário:Polyana Cristine Tizioto
Linha de fomento: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado