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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Perinatal Exposure to Androgen Excess and the Effects on the Rat Uterine Estradiol Responsiveness

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Autor(es):
Guerra, Marina T. ; Sanabria, Marciana ; Petrusz, Peter ; Kempinas, Wilma De Grava
Número total de Autores: 4
Tipo de documento: Artigo Científico
Fonte: ENVIRONMENTAL TOXICOLOGY; v. 31, n. 11, p. 1460-1468, NOV 2016.
Citações Web of Science: 0
Resumo

Androgen exposure during sexual development induces alterations in steroidal target tissues. The objective of this study was to evaluate the uterine responsiveness to estradiol after perinatal androgenization. Pregnant Wistar rats were exposed to corn oil or testosterone propionate at 0.05, 0.1, or 0.2 mg/kg from gestational day 12 until postnatal day 21. Female offspring was challenged with estradiol (E-2) after weaning (0.4 mg/kg) and at adulthood (10 or 100 mg/day), when the pituitary response was also evaluated. At adulthood, control and 0.05 mg/kg groups presented a uterine weight increment when exposed to 100 mg/day of E-2, 0.1 mg/kg group only responded to 10 mg/day of E-2, and the 0.2 mg/kg group showed increased uterine weight at both doses. The pituitary weight was similarly increased after estradiol stimulation in all experimental groups. In conclusion, testosterone propionate exposure induced an abnormal stimulation of uterine tissue growth by estrogen stimulus without affecting pituitary response. More studies are needed to clarify whether these alterations are capable of impairing the reproductive capacity of the female tract. (C) 2015 Wiley Periodicals, Inc. (AU)

Processo FAPESP: 09/00352-9 - Estrutura do trato genital e função reprodutiva de ratas expostas a propionato de testosterona in útero e durante a lactação
Beneficiário:Marina Trevizan Guerra
Linha de fomento: Bolsas no Brasil - Doutorado