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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Cerebral microvascular blood flow and CO2 reactivity in pulmonary arterial hypertension

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Treptow, Erika ; Oliveira, Mayron F. ; Soares, Aline ; Ramos, Roberta P. ; Medina, Luiz ; Lima, Rita ; Alencar, Maria Clara ; Ferreira, Eloara Vieira ; Ota-Arakaki, Jaquelina S. ; Tufik, Sergio ; Nery, Luiz E. ; Sittencourt, Lia Rita ; Alberto Neder, J.
Número total de Autores: 13
Tipo de documento: Artigo Científico
Fonte: Respiratory Physiology & Neurobiology; v. 233, p. 60-65, NOV 2016.
Citações Web of Science: 4
Resumo

Hypocapnia and endothelial dysfunction might impair microvascular cerebral blood flow (CBFmicr) and cerebrovascular reactivity to CO2 (CVRCO2). Pulmonary arterial hypertension (PAH) is characteristically associated with chronic alveolar hyperventilation and microvascular endothelial dysfunction. We therefore determined CBFmicr (pre-frontal blood flow index (BFI) by the indocyanine green-near infrared spectroscopy methodology) during hypocapnia and hypercapnia in 25 PAH patients and 10 gender- and age-matched controls. Cerebral BFI was lower in patients than controls at similar transcutaneous PCO2 (PtcCO(2)) levels in both testing conditions. In fact, while BFI increased from hypocapnia to hypercapnia in all controls, it failed to increase in 17/25 (68%) patients. Thus, BFI increased to a lesser extent from hypo to hypercapnia ({''}Delta{''}) in patients, i.e., they showed lower Delta BFI/Delta PtcCO(2) ratios than controls. In conclusion, CBFmicr and CVRCO2 are lessened in clinically stable, mildly-impaired patients with PAH. These abnormalities might be associated with relevant clinical outcomes (hyperventilation and dyspnea, cognition, cerebrovascular disease) being potentially amenable to pharmacological treatment. (C) 2016 Elsevier B.V. All rights reserved. (AU)

Processo FAPESP: 11/52102-6 - Integrando a resposta ventilatoria e a reatividade vascular cerebral ao co2 aos disturbios respiratorios do sono em pacientes com hipertensao arterial pulmonar.
Beneficiário:José Alberto Neder Serafini
Linha de fomento: Auxílio à Pesquisa - Regular