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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Oestradiol effects on neuroendocrine responses induced by water deprivation in rats

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Vilhena-Franco, Tatiane ; Mecawi, Andre Souza ; Kagohara Elias, Lucila Leico ; Antunes-Rodrigues, Jose
Número total de Autores: 4
Tipo de documento: Artigo Científico
Fonte: Journal of Endocrinology; v. 231, n. 2, p. 167-180, NOV 2016.
Citações Web of Science: 6

Water deprivation (WD) induces changes in plasma volume and osmolality, which in turn activate several responses, including thirst, the activation of the renin-angiotensin system (RAS) and vasopressin (AVP) and oxytocin (OT) secretion. These systems seem to be influenced by oestradiol, as evidenced by the expression of its receptor in brain areas that control fluid balance. Thus, we investigated the effects of oestradiol treatment on behavioural and neuroendocrine changes of ovariectomized rats in response to WD. We observed that in response to WD, oestradiol treatment attenuated water intake, plasma osmolality and haematocrit but did not change urinary volume or osmolality. Moreover, oestradiol potentiated WD-induced AVP secretion, but did not alter the plasma OT or angiotensin II (Ang II) concentrations. Immunohistochemical data showed that oestradiol potentiated vasopressinergic neuronal activation in the lateral magnocellular PVN (PaLM) and supraoptic (SON) nuclei but did not induce further changes in Fos expression in the median preoptic nucleus (MnPO) or subfornical organ (SFO) or in oxytocinergic neuronal activation in the SON and PVN of WD rats. Regarding mRNA expression, oestradiol increased OT mRNA expression in the SON and PVN under basal conditions and after WD, but did not induce additional changes in the mRNA expression for AVP in the SON or PVN. It also did not affect the mRNA expression of RAS components in the PVN. In conclusion, our results show that oestradiol acts mainly on the vasopressinergic system in response to WD, potentiating vasopressinergic neuronal activation and AVP secretion without altering AVP mRNA expression. (AU)

Processo FAPESP: 10/05436-3 - Papel dos receptores NMDA e AMPA na secreção de AVP e OT induzida por alterações de volume ou osmolalidade do líquido extracelular
Beneficiário:Tatiane Vilhena Franco
Linha de fomento: Bolsas no Brasil - Doutorado