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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Effects of budlein A on human neutrophils and lymphocytes

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Autor(es):
Knob, Carollinie Dias ; da Silva, Milena ; Gasparoto, Thais Helena ; de Oliveira, Carine Ervolino ; Amor, Nadia Ghinelli ; Arakawa, Nilton Syogo ; da Costa, Fernando Batista ; Campanelli, Ana Paula
Número total de Autores: 8
Tipo de documento: Artigo Científico
Fonte: Journal of Applied Oral Science; v. 24, n. 3, p. 271-277, MAY-JUN 2016.
Citações Web of Science: 3
Resumo

Sesquiterpene lactones (SLs) are the active constituents of a variety of medicinal plants used in traditional medicine for the treatment of inflammatory diseases and other ailments. Objective: In this study, we evaluated whether budlein A modulates the activation of innate and adaptive immune cells such as neutrophils and lymphocytes. Material and Methods: Our research group has investigated several plant species and several compounds have been isolated, identified, and their medical potential evaluated. Budlein A is a SL isolated from the species Aldama buddlejiformis and A. robusta (Asteraceae) and shows anti-inflammatory and anti-nociceptive activities. Advances in understanding how plant-derived substances modulate the activation of innate and adaptive immune cells have led to the development of new therapies for human diseases. Results: Budlein A inhibited MPO activity, IL-6, CXCL8, IL-10, and IL-12 production and induces neutrophil apoptosis. In contrast, budlein A inhibited lymphocyte proliferation and IL-2, IL-10, TGF-beta, and IFN-gamma production, but it did not lead to cell death. Conclusions: Collectively, our results indicate that budlein A shows distinct immunomodulatory effects on immune cells. (AU)

Processo FAPESP: 08/57149-8 - Potencial químico e farmacológico de espécies da familia Asteraceae: estudos integrados in vivo, in vitro e in silico
Beneficiário:Fernando Batista da Costa
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 08/09554-0 - Análise do efeito de budleína a na ativação de linfócitos
Beneficiário:Carollinie Dias Knob
Linha de fomento: Bolsas no Brasil - Iniciação Científica
Processo FAPESP: 08/03931-7 - Análise do efeito de Budleína a na ativação de neutrófilos
Beneficiário:Milena da Silva
Linha de fomento: Bolsas no Brasil - Iniciação Científica