Gene expression alterations related to mania and psychosis in peripheral blood of patients with a first episode of psychosis

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Gouvea, E. S. ; Ota, V. K. ; Noto, C. ; Santoro, M. L. ; Spindola, L. M. ; Moretti, P. N. ; Carvalho, C. M. ; Xavier, G. ; Rios, A. C. ; Sato, J. R. ; Hayashi, M. A. F. ; Brietzke, E. ; Gadelha, A. ; Bressan, R. A. ; Cordeiro, Q. ; Belangero, S. I.

• Tipo de documento: Artigo Científico
• Fonte: TRANSLATIONAL PSYCHIATRY; v. 6, OCT 4 2016.
• Citações Web of Science: 9

Resumo

Psychotic disorders affect similar to 3% of the general population and are among the most severe forms of mental diseases. In early stages of psychosis, clinical aspects may be difficult to distinguish from one another. Undifferentiated psychopathology at the first-episode of psychosis (FEP) highlights the need for biomarkers that can improve and refine differential diagnosis. We investigated gene expression differences between patients with FEP-schizophrenia spectrum (SCZ; N = 53) or FEP-Mania (BD; N = 16) and healthy controls (N = 73). We also verified whether gene expression was correlated to severity of psychotic, manic, depressive symptoms and/or functional impairment. All participants were antipsychotic-naive. After the psychiatric interview, blood samples were collected and the expression of 12 psychotic-disorder-related genes was evaluated by quantitative PCR. AKT1 and DICER1 expression levels were higher in BD patients compared with that in SCZ patients and healthy controls, suggesting that expression of these genes is associated more specifically to manic features. Furthermore, MBP and NDEL1 expression levels were higher in SCZ and BD patients than in healthy controls, indicating that these genes are psychosis related (independent of diagnosis). No correlation was found between gene expression and severity of symptoms or functional impairment. Our findings suggest that genes related to neurodevelopment are altered in psychotic disorders, and some might support the differential diagnosis between schizophrenia and bipolar disorder, with a potential impact on the treatment of these disorders. (AU)

• Processo FAPESP: 11/50740-5 - Prevenção na esquizofrenia e no transtorno bipolar da neurociência à comunidade: uma plataforma multifásica, multimodal e translacional para investigação e intervenção
• Beneficiário: Rodrigo Affonseca Bressan
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 14/50830-2 - Biomarcadores genéticos em pacientes com psicose virgens de tratamento
• Beneficiário: Rodrigo Affonseca Bressan
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 12/12686-1 - Busca por potenciais marcadores genéticos nas fases iniciais da esquizofrenia
• Beneficiário: Marcos Leite Santoro
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 13/10498-6 - Aprendizado de máquina em neuroimagem: desenvolvimento de métodos e aplicações clínicas em transtornos psiquiátricos
• Beneficiário: João Ricardo Sato
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 10/08968-6 - Investigação de marcadores genéticos e epigenéticos: uma abordagem translacional para o tratamento de esquizofrenia
• Beneficiário: Síntia Iole Nogueira Belangero
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/07280-1 - Busca por marcadores genéticos de risco, de progressão e de reposta ao tratamento na esquizofrenia
• Beneficiário: Síntia Iole Nogueira Belangero
• Modalidade de apoio: Auxílio à Pesquisa - Regular