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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Marrow adipose tissue spectrum in obesity and type 2 diabetes mellitus

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Autor(es):
de Araujo, Iana M. ; Salmon, Carlos E. G. ; Nahas, Andressa K. ; Nogueira-Barbosa, Marcello H. ; Elias, Jr., Jorge ; de Paula, Francisco J. A.
Número total de Autores: 6
Tipo de documento: Artigo Científico
Fonte: EUROPEAN JOURNAL OF ENDOCRINOLOGY; v. 176, n. 1, p. 21-30, JAN 2017.
Citações Web of Science: 15
Resumo

Objective: To assess the association of bone mass and marrow adipose tissue (MAT) with other fat depots, insulin resistance, bone remodeling markers, adipokines and glucose control in type 2 diabetes and obesity. Design and methods: The study groups comprised 24 controls (C), 26 obese (O) and 28 type 2 diabetes. Dual-energy X-ray absorptiometry was used to determine bone mineral density (BMD). Blood samples were collected for biochemical measurements. H-1 Magnetic resonance spectroscopy was used to assess MAT in the L3 vertebra, and abdominal magnetic resonance imaging was used to assess intrahepatic lipids in visceral (VAT) and subcutaneous adipose tissue. Regression analysis models were used to test the association between parameters. Results: At all sites tested, BMD was higher in type 2 diabetes than in O and C subjects. The C group showed lower VAT values than the type 2 diabetes group and lower IHL than the O and type 2 diabetes groups. However, MAT was similar in the 3 groups. Osteocalcin and C-terminal telopeptide of type 1 collagen were lower in type 2 diabetes than those in C and O subjects. Moreover, at all sites, BMD was negatively associated with osteocalcin. No association was observed between MAT and VAT. No relationship was observed among MAT and HOMA-IR, leptin, adiponectin or Pref-1, but MAT was positively associated with glycated hemoglobin. Conclusions: MAT is not a niche for fat accumulation under conditions of energy surplus and type 2 diabetes, also is not associated with VAT or insulin resistance. MAT is associated with glycated hemoglobin. (AU)

Processo FAPESP: 12/09527-9 - Valor preditivo da quantificação de adiposidade visceral e óssea sobre densidade mineral óssea e ocorrência de fratura no diabetes mellitus tipo 2
Beneficiário:Iana Mizumukai de Araujo
Linha de fomento: Bolsas no Brasil - Mestrado
Processo FAPESP: 12/14603-6 - Valor preditivo da quantificação de adiposidade visceral e óssea sobre densidade mineral óssea e ocorrência de fratura no Diabetes Mellitus tipo 2
Beneficiário:Francisco José Albuquerque de Paula
Linha de fomento: Auxílio à Pesquisa - Regular