Protective efficacy of multiple vaccine platforms against Zika virus challenge in rhesus monkeys

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Abbink, Peter ; Larocca, Rafael A. ; De La Barrera, Rafael A. ; Bricault, Christine A. ; Moseley, Edward T. ; Boyd, Michael ; Kirilova, Marinela ; Li, Zhenfeng ; Ng'ang'a, David ; Nanayakkara, Ovini ; Nityanandam, Ramya ; Mercado, Noe B. ; Borducchi, Erica N. ; Agarwal, Arshi ; Brinkman, Amanda L. ; Cabral, Crystal ; Chandrashekar, Abishek ; Giglio, Patricia B. ; Jetton, David ; Jimenez, Jessica ; Lee, Benjamin C. ; Mojta, Shanell ; Molloy, Katherine ; Shetty, Mayuri ; Neubauer, George H. ; Stephenson, Kathryn E. ; Peron, Jean Pierre S. ; Zanotto, Paolo M. de A. ; Misamore, Johnathan ; Finneyfrock, Brad ; Lewis, Mark G. ; Alter, Galit ; Modjarrad, Kayvon ; Jarman, Richard G. ; Eckels, Kenneth H. ; Michael, Nelson L. ; Thomas, Stephen J. ; Barouch, Dan H.

• Tipo de documento: Artigo Científico
• Fonte: Science; v. 353, n. 6304, p. 1129-1132, SEP 9 2016.
• Citações Web of Science: 227

Resumo

Zika virus (ZIKV) is responsible for a major ongoing epidemic in the Americas and has been causally associated with fetal microcephaly. The development of a safe and effective ZIKV vaccine is therefore an urgent global health priority. Here we demonstrate that three different vaccine platforms protect against ZIKV challenge in rhesus monkeys. A purified inactivated virus vaccine induced ZIKV-specific neutralizing antibodies and completely protected monkeys against ZIKV strains from both Brazil and Puerto Rico. Purified immunoglobulin from vaccinated monkeys also conferred passive protection in adoptive transfer studies. A plasmid DNA vaccine and a single-shot recombinant rhesus adenovirus serotype 52 vector vaccine, both expressing ZIKV premembrane and envelope, also elicited neutralizing antibodies and completely protected monkeys against ZIKV challenge. These data support the rapid clinical development of ZIKV vaccines for humans. (AU)

• Processo FAPESP: 14/17766-9 - Abordagem sistêmica no estudo da permissividade do Anticarsia gemmatalis múltiplo nucleopoliedrovírus (AgMNPV)
• Beneficiário: Paolo Marinho de Andrade Zanotto
• Linha de fomento: Auxílio à Pesquisa - Regular
• Processo FAPESP: 11/18703-2 - O papel do eixo triptofano - Kinureninas na regulação da resposta imune através de receptores de glutamato tipo NMDA na encefalomielite experimental auto-imune e na lesão por isquemia e reperfusão cerebral
• Beneficiário: Jean Pierre Schatzmann Peron
• Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores