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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Small leucine-rich proteoglycans (SLRPs) in uterine tissues during pregnancy in mice

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Autor(es):
San Martin, S. [1] ; Soto-Suazo, M. ; Oliveira, S. F. de ; Aplin, J. D. ; Abrahamsohn, P. ; Zorn, T. M.T
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Universidade de São Paulo (USP). Instituto de Ciências Biomédicas. Departamento de Biologia Celular e do Desenvolvimento - Brasil
Número total de Afiliações: 6
Tipo de documento: Artigo Científico
Fonte: Reproduction; v. 125, n. 4, p. 585-595, Apr. 2003.
Área do conhecimento: Ciências Biológicas - Morfologia
Assunto(s):Histologia   Imuno-histoquímica   Matriz extracelular   Endométrio   Colágeno
Resumo

Remodelling of the extracellular matrix (ECM) occurs during decidualization of the endometrium in mice. Previously we have documented the appearance of large-diameter collagen fibrils around mature decidual cells between day 5 and day 7 of pregnancy. Proteoglycans are important in the regulation of collagen fibrillogenesis, and the present study analysed four members (decorin, biglycan, lumican and fibromodulin) of the family of small leucine-rich proteoglycans (SLRPs) in the uterus from day 1 to day 7 of pregnancy. Decorin was present together with lesser amounts of lumican in the stroma before the onset of decidualization, whereas biglycan and fibromodulin were almost absent. Biglycan and, less significantly, lumican were expressed in decidualized regions of the endometrium, but decorin was absent. Fibromodulin was weakly expressed in the non-decidualized stroma, but only after implantation. Decorin and lumican were strongly expressed in the undifferentiated interimplantation site stroma, whereas biglycan and fibromodulin were expressed only weakly. These results indicate that the SLRP profile of the uterine ECM alters with differentiation of endometrial stromal cells. The large decidual collagen fibrils are thought to arise by lateral association of smaller diameter fibrils. As decorin has been shown to inhibit lateral association of collagen fibrils, its disappearance between day 2 and day 5 of pregnancy may be a prerequisite for the formation of large fibrils in decidua in mice. (AU)

Processo FAPESP: 00/04078-4 - Caracterizacao e distribuicao de proteoglicanos da matriz extracelular no processo de decidualizacao do endometrio em camundongos.
Beneficiário:Sebastian Andres San Martin Henriquez
Linha de fomento: Bolsas no Brasil - Mestrado
Processo FAPESP: 01/12283-0 - Expressão, caracterização e distribuição de alguns tipos de proteoglicanos no endométrio durante a gestação em camundongos: efeito da castração e da reposição hormonal
Beneficiário:Sebastian Andres San Martin Henriquez
Linha de fomento: Bolsas no Brasil - Doutorado Direto