Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Quantum-chemistry descriptors for photosensitizers based on macrocycles

Texto completo
Autor(es):
Bettanin, Fernanda ; Antonio, Felipe C. T. ; Honorio, Kathia M. ; Homem-de-Mello, Paula
Número total de Autores: 4
Tipo de documento: Artigo Científico
Fonte: CHEMICAL BIOLOGY & DRUG DESIGN; v. 89, n. 2, p. 207-220, FEB 2017.
Citações Web of Science: 3
Resumo

Phthalocyanines, porphyrins, and chlorins have been widely studied as photosensitizers. Both experimental and computational strategies are employed in order to propose new and more active molecules derived from those macrocycles. In this context, there are two main strategies used: (i) the addition of different substituents and (ii) the complexation of the macrocycle with different metallic ions. In this work, we present selected descriptors based on quantum chemistry calculations for forty macrocycles, including some approved drugs. We have found that density functional theory is a suitable methodology to study the large sets of molecules when applying the B3LYP/LanL2DZ methodology for geometry optimization and TD-OLYP/6-31G(d) for absorption spectrum. The inclusion of solvent effects by means of continuum model is important in order to obtain the accurate electronic data. We have verified that by bonding charged or polar substituents to the macrocycle, it is possible to enhance water solvation as well as to improve spectroscopic properties because molecular orbital contributions for Q band can be affected by some substituents. Selected descriptors, electronic and steric, were pointed out as important to propose the new photosensitizers. (AU)

Processo FAPESP: 10/19790-3 - Estudo teórico de porfirinas, ftalocianinas e clorinas com ênfase para aplicação em terapia fotodinâmica
Beneficiário:Fernanda Bettanin
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 12/50680-5 - Fotossensibilização nas ciências da vida
Beneficiário:Mauricio da Silva Baptista
Linha de fomento: Auxílio à Pesquisa - Temático