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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Dyslipidemia rather than Type 2 Diabetes Mellitus or Chronic Periodontitis Affects the Systemic Expression of Pro-and Anti-Inflammatory Genes

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Autor(es):
Nepomuceno, Rafael ; Villela, Barbara Scoralick ; Tfaile Corbi, Samia Cruz ; Bastos, Alliny De Souza ; Dos Santos, Raquel Alves ; Takahashi, Catarina Satie ; Perez Orrico, Silvana Regina ; Scarel-Caminaga, Raquel Mantuaneli
Número total de Autores: 8
Tipo de documento: Artigo Científico
Fonte: Mediators of Inflammation; 2017.
Citações Web of Science: 3
Resumo

A high percentage of type 2 diabetes mellitus (T2D) patients are also affected by dyslipidemia and chronic periodontitis (CP), but no studies have determined the gene expression in patients that are simultaneously affected by all three diseases. We investigated the systemic expression of immune-related genes in T2D, dyslipidemia, and CP patients. One hundred and fifty patients were separated into five groups containing 30 individuals each: (G1) poorly controlled T2D with dyslipidemia and CP; (G2) well-controlled T2D with dyslipidemia and CP; (G3) normoglycemic individuals with dyslipidemia and CP; (G4) healthy individuals with CP; (G5) systemic and periodontally healthy individuals. Blood analyses of lipid and glycemic profiles were carried out. The expression of genes, including IL10, JAK1, STAT3, SOCS3, IP10, ICAM1, IFNA, IFNG, STAT1, and IRF1, was investigated by RT-qPCR. Patients with dyslipidemia demonstrated statistically higher expression of the IL10 and IFNA genes, while IFNG, IP10, IRF1, JAK1, and STAT3 were lower in comparison with nondyslipidemic patients. Anti-inflammatory genes, such as IL10, positively correlated with parameters of glucose, lipid, and periodontal profiles, while proinflammatory genes, such as IFNG, were negatively correlated with these parameters. We conclude that dyslipidemia appears to be the primary disease that is associated with gene expression of immune-related genes, while parameters of T2D and CP were correlated with the expression of these important immune genes. (AU)

Processo FAPESP: 07/08362-8 - Avaliação da correlação entre peroxidação lipídica e o perfil de marcadores inflamatórios em pacientes portadores de diabetes mellitus tipo 2 com periodontite crônica
Beneficiário:Silvana Regina Perez Orrico
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 10/10882-2 - Expressão gênica em indivíduos portadores de Diabetes mellitus tipo 2, dislipidemia e doença periodontal: avaliação por microarray
Beneficiário:Raquel Mantuaneli Scarel Caminaga
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 09/16233-9 - Avaliação do efeito da descompensação do diabetes mellitus sobre a expressão de genes do sistema imune e sobre lesões no DNA em pacientes com periodontite crônica
Beneficiário:Sâmia Cruz Tfaile Corbi
Linha de fomento: Bolsas no Brasil - Doutorado