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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

The intestinal microbiota in allogeneic hematopoietic cell transplant and graft-versus-host disease

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Autor(es):
Staffas, Anna ; da Silva, Marina Burgos ; van den Brink, Marcel R. M.
Número total de Autores: 3
Tipo de documento: Artigo de Revisão
Fonte: Blood; v. 129, n. 8, p. 927-933, FEB 23 2017.
Citações Web of Science: 41
Resumo

Hematopoietic cell transplantation (HCT) is a critical treatment of patients with high-risk hematopoietic malignancies, hematological deficiencies, and other immune diseases. In allogeneic HCT (allo-HCT), donor-derived T cells recognize host tissues as foreign, causing graft-versus-host disease (GVHD) which is a main contributor to morbidity and mortality. The intestine is one of the organs most severely affected by GVHD and research has recently highlighted the importance of bacteria, particularly the gut microbiota, in HCT outcome and in GVHD development. Loss of intestinal bacterial diversity is common during the course of HCT and is associated with GVHD development and treatment with broad-spectrum antibiotics. Loss of intestinal diversity and outgrowth of opportunistic pathogens belonging to the phylum Proteobacteria and Enterococcus genus have also been linked to increased treatment-related mortality including GVHD, infections, and organ failure after allo-HCT. Experimental studies in allo-HCT animal models have shown some promising results for prebiotic and probiotic strategies as prophylaxisor treatment of GVHD. Continuous research will be important to define the relation of cause and effect for these associations between microbiota features and HCT outcomes. Importantly, studies focused on geographic and cultural differences in intestinal microbiota are necessary to define applicability of new strategies targeting the intestinal microbiota. (AU)

Processo FAPESP: 15/14370-0 - Papel da obesidade e microbiota intestinal associada à obesidade na doença do enxerto-versus-hospedeiro (GVHD)
Beneficiário:Marina Burgos da Silva
Linha de fomento: Bolsas no Exterior - Estágio de Pesquisa - Doutorado