VEGF gene polymorphisms and outcome of epithelial ovarian cancer patients

Autor(es)

Camerin, Gabriela Ribeiro ; Carvalho Brito, Angelo Borsarelli ; Vassallo, Jose ; Mauricette Derchain, Sophie Francoise ; Passos Lima, Carmen Silvia

• Tipo de documento: Artigo Científico
• Fonte: FUTURE ONCOLOGY; v. 13, n. 5, p. 409-414, FEB 2017.
• Citações Web of Science: 6

Resumo

Aim: Since VEGF polymorphisms were associated with variable protein production, we analyzed herein their roles in outcome of epithelial ovarian cancer (EOC) patients. Methods: Genotypes of 85 patients with primary EOC were identified in DNA by real-time PCR. Progression-free survival and overall survival were analyzed using Kaplan-Meier method, univariate Cox model and bootstrap resampling study. Results: At 60 months of follow-up, progression-free survival was shorter in patients with VEGF c.-2578 CC genotype compared with others (52.7 vs 82.2%; p = 0.04). Those patients had 2.15 more chance of presenting disease progression than others (p = 0.04); bootstrap study validated the result (p = 0.03). Conclusion: Our data suggest that VEGF c.-2578C>A polymorphism acts as a prognostic factor in EOC. (AU)

• Processo FAPESP: 06/01710-8 - Avaliacao da predisposicao hereditaria a neoplasias.
• Beneficiário: Carmen Silvia Passos Lima
• Modalidade de apoio: Auxílio à Pesquisa - Regular