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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Multimodal evaluation of ultra-short laser pulses treatment for skin burn injuries

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Autor(es):
dos Santos, Moises Oliveira ; Latrive, Anne ; Augusto de Castro, Pedro Arthur ; de Rossi, Wagner ; Tenorio Zorn, Telma Maria ; Samad, Ricardo Elgul ; Freitas, Anderson Zanardi ; Cesar, Carlos Lenz ; Vieira Junior, Nilson Dias ; Zezell, Denise Maria
Número total de Autores: 10
Tipo de documento: Artigo Científico
Fonte: BIOMEDICAL OPTICS EXPRESS; v. 8, n. 3, p. 1575-1588, MAR 1 2017.
Citações Web of Science: 2
Resumo

Thousands of people die every year from burn injuries. The aim of this study is to evaluate the feasibility of high intensity femtosecond lasers as an auxiliary treatment of skin burns. We used an in vivo animal model and monitored the healing process using 4 different imaging modalities: histology, Optical Coherence Tomography (OCT), Second Harmonic Generation (SHG), and Fourier Transform Infrared (FTIR) spectroscopy. 3 dorsal areas of 20 anesthetized Wistar rats were burned by water vapor exposure and subsequently treated either by classical surgical debridement, by laser ablation, or left without treatment. Skin burn tissues were non-invasively characterized by OCT images and biopsied for further histopathology analysis, SHG imaging and FTIR spectroscopy at 3, 5, 7 and 14 days after burn. The laser protocol was found as efficient as the classical treatment for promoting the healing process. The study concludes to the validation of femtosecond ultra-short pulses laser treatment for skinburns, with the advantage of minimizing operatory trauma. (C) 2017 Optical Society of America (AU)

Processo FAPESP: 05/51689-2 - Centro de Pesquisa em Óptica e Fotônica - UNICAMP (CEPOF-UNICAMP)
Beneficiário:Hugo Luis Fragnito
Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
Processo FAPESP: 11/51959-0 - Biologia das doenças neoplásicas da medula óssea
Beneficiário:Sara Teresinha Olalla Saad
Linha de fomento: Auxílio à Pesquisa - Temático