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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Intrauterine growth restriction increases circulating mitochondrial DNA and Toll-like receptor 9 expression in adult offspring: could aerobic training counteract these adaptations?

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Autor(es):
Oliveira, V. ; Silva Junior, S. D. ; de Carvalho, M. H. C. ; Akamine, E. H. ; Michelini, L. C. ; Franco, M. C.
Número total de Autores: 6
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE; v. 8, n. 2, p. 236-243, APR 2017.
Citações Web of Science: 1
Resumo

It has been demonstrated that intrauterine growth restriction (IUGR) can program increase cardiometabolic risk. There are also evidences of the correlation between IUGR with low-grade inflammation and, thus can contribute to development of several cardiometabolic comorbidities. Therefore, we investigated the influence of IUGR on circulating mitochondrial DNA (mtDNA)/Toll-like receptor 9 (TLR9) and TNF-alpha expression in adult offspring. Considering that the aerobic training has anti-inflammatory actions, we also investigated whether aerobic training would improve these inflammatory factors. Pregnant Wistar rats received ad libitum or 50% of ad libitum diet throughout gestation. At 8 weeks of age, male offspring from both groups were randomly assigned to control, trained control, restricted and trained restricted. Aerobic training protocol was performed on a treadmill and after that, we evaluated circulating mtDNA, cardiac protein expression of TLR9, plasma and cardiac TNF-levels, and left ventricle (LV) mass. We found that IUGR promoted an increase in the circulating mtDNA, TLR9 expression and plasma TNF-alpha levels. Further, our results revealed that aerobic training can restore mtDNA/TLR9 content and plasma levels of TNF-alpha among restricted rats. The cardiac TNF-alpha content and LV mass were not influenced either by IUGR or aerobic training. In conclusion, IUGR can program mtDNA/TLR9 content, which may lead to high levels of TNF-alpha. However, aerobic training was able to normalize these alterations. These findings evidenced that the association of IUGR and aerobic training seems to exert an important interaction effect regarding pro-inflammatory condition and, aerobic training may be used as a strategy to reduce deleterious adaptations in IUGR offspring. (AU)

Processo FAPESP: 13/00311-6 - Isolamento e caracterização de células progenitoras endoteliais circulantes e de medula óssea de ratos submetidos à restrição de nutrientes in útero: avaliação do impacto do treinamento físico aeróbio e do balanço redox
Beneficiário:Vanessa Aparecida de Oliveira
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 13/03139-0 - Inter-relação do peso ao nascer, treinamento físico e níveis pressóricos: uma abordagem clínica e experimental sobre o papel das células progenitoras endoteliais
Beneficiário:Maria Do Carmo Pinho Franco
Linha de fomento: Auxílio à Pesquisa - Regular