Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

High Prevalence of ITPA Alleles Associated with Ribavirin-Induced Hemolytic Anemia Among Mexican Population

Texto completo
Autor(es):
Gonzalez-Aldaco, Karina ; Panduro, Arturo ; Pinho, Joao R. Rebello ; Martinez-Lopez, Erika ; Gleyzer, Ketti ; Fierro, Nora A. ; Roman, Sonia
Número total de Autores: 7
Tipo de documento: Artigo Científico
Fonte: ANNALS OF HEPATOLOGY; v. 16, n. 2, p. 221-229, MAR-APR 2017.
Citações Web of Science: 4
Resumo

Background. The prevalence of two functional polymorphisms (rs1127354 and rs7270101) of the inosine triphosphates (ITPA) gene associated with ribavirin induced hemolytic anemia (RIHA) during antiviral therapy for hepatitis C virus (HCV) infection varies by ethnicity. In Mexico, the distribution of these polymorphisms among Native Amerindians (NA) and admixed population (Mestizos) is unknown. This study aimed to determine the prevalence of the ITPA polymorphisms among healthy NA and Mestizos, as well as in HCV patients from West Mexico. Material and methods. In a cross-sectional study, 600 unrelated subjects (322 Mestizos, 100 NA, and 178 treatment naive, HCV-infected Mestizos patients) were enrolled. A medical history was registered. ITPA genotype was determined by Real-Time PCR. Fct-values and genetic relatedness between study and reference poplulation were assessed. Results. The frequency of the risk genotypes rs1 127354CC and 7270101AA was higher among NA (98-100%) than in Mestizos (87-92.9%), (p < 0.05). The NA presented the highest prevalence of the rs1 127354CC genotype reported worldwide. The Fst-values revealed a genetic relatedness among Mexican NA (98%) than in Mestizos (80.5%) and HCV-infected patients (81.5%) (p < 0.01). The CC/AA alleles were associated with lower values of total bilirubin, aspartate/alanine aminotransferases, and aspartate-to-plate-let-ratio-index score among HCV-patients. Conclusion. A high prevalence of the ITPA polymorphisms associated with RIHA was found in Mexican NA. These polymorphisms could be a useful tool for evaluating potential adverse effects and the risk or benefit of antiviral therapy in Mexicans and the admixed populations. (AU)

Processo FAPESP: 10/10549-1 - Genotipagem dos polimorfismos de base única do gene da IL-28 em indivíduos infectados pelo vírus da hepatite C
Beneficiário:João Renato Rebello Pinho
Linha de fomento: Auxílio à Pesquisa - Regular