Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Resistance Exercise Reduces Seizure Occurrence, Attenuates Memory Deficits and Restores BDNF Signaling in Rats with Chronic Epilepsy

Texto completo
Autor(es):
de Almeida, Alexandre Aparecido ; da Silva, Sergio Gomes ; Lopim, Glauber Menezes ; Campos, Diego Vannucci ; Fernandes, Jansen ; Cabral, Francisco Romero ; Arida, Ricardo Mario
Número total de Autores: 7
Tipo de documento: Artigo Científico
Fonte: Neurochemical Research; v. 42, n. 4, p. 1230-1239, APR 2017.
Citações Web of Science: 6
Resumo

Epilepsy is a disease characterized by recurrent, unprovoked seizures. Cognitive impairment is an important comorbidity of chronic epilepsy. Human and animal model studies of epilepsy have shown that aerobic exercise induces beneficial structural and functional changes and reduces the number of seizures. However, little is yet understood about the effects of resistance exercise on epilepsy. We evaluated the effects of a resistance exercise program on the number of seizures, long- term memory and expression/ activation of signaling proteins in rats with epilepsy. The number of seizures was quantified by video- monitoring and long- term memory was assessed by an inhibitory avoidance test. Using western blotting, multiplex and enzyme- linked immunosorbent assays, we determined the effects of a 4- week resistance exercise program on IGF- 1 and BDNF levels and ERK, CREB, mTOR activation in the hippocampus of rats with epilepsy. Rats with epilepsy submitted to resistance exercise showed a decrease in the number of seizures compared to non- exercised epileptic rats. Memory deficits were attenuated by resistance exercise. Rats with epilepsy showed an increase in IGF- 1 levels which were restored to control levels by resistance exercise. BDNF levels and ERK and mTOR activation were decreased in rats with epilepsy and resistance exercise restored these to control levels. In conclusion, resistance exercise reduced seizure occurrence and mitigated memory deficits in rats with epilepsy. These resistance exerciseinduced beneficial effects can be related to changes in IGF- 1 and BDNF levels and its signaling protein activation. Our findings indicate that the resistance exercise might be included as complementary therapeutic strategy for epilepsy treatment. (AU)

Processo FAPESP: 13/12692-4 - Influência do exercício aeróbico sobre a expressão e a distribuição de microRNAs na formação hipocampal de ratos adultos
Beneficiário:Ricardo Mario Arida
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 14/00035-1 - Reserva neural induzida pela prática de atividade física na adolescência: um estudo do fator neurotrófico derivado do encéfalo (BDNF), de seus receptores (TrkB e P75ntr) e vias de sinalização intracelular
Beneficiário:Sérgio Gomes da Silva
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 11/50680-2 - Investigação multimodal da epileptogênese com ênfase na incorporação de novos modelos e novas ferramentas
Beneficiário:Iscia Teresinha Lopes Cendes
Linha de fomento: Auxílio à Pesquisa - Temático