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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Geographic heterogeneity in the prevalence of human papillomavirus in head and neck cancer

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Anantharaman, Devasena ; Abedi-Ardekani, Behnoush ; Beachler, Daniel C. ; Gheit, Tarik ; Olshan, Andrew F. ; Wisniewski, Kathy ; Wunsch-Filho, Victor ; Toporcov, Tatiana N. ; Tajara, Eloiza H. ; Levi, Jose Eduardo ; Moyses, Raquel A. ; Boccia, Stefania ; Cadoni, Gabriella ; Rindi, Guido ; Ahrens, Wolfgang ; Merletti, Franco ; Conway, David I. ; Wright, Sylvia ; Carreira, Christine ; Renard, Helene ; Chopard, Priscilia ; McKay-Chopin, Sandrine ; Scelo, Ghislaine ; Tommasino, Massimo ; Brennan, Paul ; D'Souza, Gypsyamber
Número total de Autores: 26
Tipo de documento: Artigo Científico
Fonte: International Journal of Cancer; v. 140, n. 9, p. 1968-1975, MAY 1 2017.
Citações Web of Science: 27
Resumo

Human papillomavirus (HPV) causes oropharyngeal squamous cell carcinoma (OPSCC), although strongly divergent results have been reported regarding the prevalence of HPV16 in different countries, whether this represents important differences in etiology remains unclear. Applying rigorous protocols for sample processing, we centrally evaluated 1,420 head and neck tumors (533 oropharynx, 395 oral cavity and 482 larynx) from studies conducted in the US, Europe and Brazil for mucosal HPV DNA and p16(INK4a) expression to evaluate regional heterogeneity in the proportion of HPV16-associated OPSCC and other head and neck cancer, and to assess covariates associated with the risk of HPV16-positive OPSCC. While majority of OPSCC in the US (60%) were HPV16-positive, this proportion was 31% in Europe and only 4% in Brazil (p < 0.01). Similar differences were observed for other head and neck tumors, ranging from 7% in the US and 5% in Europe, to 0% in South America. The odds of HPV16-positive OPSCC declined with increasing pack years of smoking (OR: 0.75; 95% CI: 0.64-0.87) and drink years of alcohol use (OR: 0.64; 95% CI: 0.54-0.76). These results suggest that while the contribution of HPV16 is substantial for the oropharynx, it remains limited for oral cavity and laryngeal cancers. (AU)

Processo FAPESP: 04/12054-9 - Busca de marcadores de agressividade em tumores de cabeça e pescoço
Beneficiário:Eloiza Helena Tajara da Silva
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 10/51168-0 - Fatores ambientais, clínicos, histopatológicos e moleculares associados ao desenvolvimento e ao prognóstico de carcinomas epidermoides de cabeça e pescoço
Beneficiário:Eloiza Helena Tajara da Silva
Linha de fomento: Auxílio à Pesquisa - Temático