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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

The influence of benign prostatic hyperplasia on sperm morphological features and sperm DNA integrity in dogs

Texto completo
Autor(es):
Flores, R. B. ; Angrimani, D. S. R. ; Rui, B. R. ; Brito, M. M. ; Abreu, R. A. ; Vannucchi, C. I.
Número total de Autores: 6
Tipo de documento: Artigo Científico
Fonte: REPRODUCTION IN DOMESTIC ANIMALS; v. 52, n. 2, SI, p. 310-315, APR 2017.
Citações Web of Science: 6
Resumo

Contents Benign prostatic hyperplasia (BPH) has a high incidence in older intact dogs. Due to the increased prostatic oxidative stress and hormonal imbalance of BPH, sperm damage can arise, such as sperm morphological alterations and DNA fragmentation. This study aimed to compare the reproductive potential of healthy dogs and those affected by benign prostatic hyperplasia. Ten dogs were assigned to two experimental groups: dogs without BPH (control; n=5) and dogs diagnosed with BPH (n=5), based on clinical signs and ultrasonographic findings. Three semen collections were performed from each dog within one month and analysed using computer-assisted sperm analysis (CASA) and functional tests. Control group showed higher percentage of sperm DNA integrity (95 +/- 1.8%) compared to the BPH group (79.2 +/- 6.4%). On the other hand, the percentage of minor sperm defects, amplitude of lateral sperm head displacement of the spermatozoa and medium sperm mitochondrial activity were higher in the BPH group. In conclusion, BPH decreases sperm DNA integrity, increases mitochondrial activity, as well as modifies sperm movement pattern. Therefore, a careful sperm analysis of aged dogs with BPH is required before a reproductive programme can be established for such patients. (AU)

Processo FAPESP: 13/25966-5 - Caracterização seminal e das alterações hemodinâmicas da próstata e testículos de cães com hiperplasia prostática benigna
Beneficiário:Daniel de Souza Ramos Angrimani
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 15/05419-5 - Senescência reprodutiva em cães: aspectos clínicos e biotecnológicos
Beneficiário:Camila Infantosi Vannucchi
Linha de fomento: Auxílio à Pesquisa - Regular