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Total renal denervation reduces sympathoexcitation to different target organs in a model of chronic kidney disease

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Autor(es):
Veiga, Glaucia L. ; Nishi, Erika E. ; Estrela, Heder F. ; Lincevicius, Gisele S. ; Gomes, Guiomar N. ; Simoes Sato, Alex Y. ; Campos, Ruy R. ; Bergamaschi, Cassia T.
Número total de Autores: 8
Tipo de documento: Artigo de Revisão
Fonte: AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL; v. 204, p. 81-87, MAY 2017.
Citações Web of Science: 5
Resumo

It is known that increased sympathetic nerve activity in chronic kidney disease (CKD) progressively worsens kidney function and hypertension. We tested the hypothesis that total renal denervation contributes to reduce sympathetic activation to different beds and improves renal function in 5/6 nephrectomy model of CKD in male Wistar rats. After eight weeks of 5/6 nephrectomy surgery there was an increase in mean arterial pressure (CKD 179 +/- 22 mm Hg, n = 6 vs. control animals 108 +/- 9; p < 0.05, n = 6) with no changes in heart rate (HR). Sympathetic nerve activity was increased at different levels to the remaining kidney, splanchnic and lumbar beds compared to control (CTL) group (CKD rSNA: 150 +/- 50, n = 9 vs. CTL 96 +/- 15, n = 9; CKD sSNA: 129 +/- 51, n = 5 vs. CTL 34 +/- 14, n = 6; CKD ISNA: 203 +/- 35, n = 8 vs. CTL 146 +/- 21, spikes/s, n = 7, p < 0.05). Three weeks after total renal denervation (DNX) MAP was normalized in the CKD rats (124 +/- 19 mm Hg, n = 5, p < 0.05), with no change in HR. The ISNA was normalized (151 +/- 40, n = 5, vs. CKD 203 +/- 35 spikes/s, n = 8) and sSNA was decreased in 49% (64 +/- 34, n = 5 vs. CKD 129 +/- 51 spikes/s, n = 5, p < 0.05). Renal function, assessed by creatinine plasma levels was improved after renal denervation (CKD 1.50 +/- 0.64, n = 8; vs. CKD + DNX 0.82 +/- 0.22 mg/mL, n = 8, p < 0.05). These findings demonstrate that renal nerves contribute to the maintenance of hypertension in CKD by increasing sympathoexcitation to other beds. (C) 2016 Elsevier B.V. All rights reserved. (AU)

Processo FAPESP: 13/22522-9 - Papel do nervo simpático renal nas alterações cardiovasculares e renais na hipertensão arterial renovascular
Beneficiário:Ruy Ribeiro de Campos Junior
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 13/23741-6 - Avaliação dos mecanismos centrais do reflexo reno-renal e o papel dos nervos aferentes renais na hipertensão renovascular
Beneficiário:Erika Emy Nishi
Linha de fomento: Bolsas no Brasil - Pós-Doutorado