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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Tumour necrosis factor-alpha-induced protein 8 (TNFAIP8) expression associated with cell survival and death in cancer cell lines infected with canine distemper virus

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Autor(es):
Garcia, J. A. ; Ferreira, H. L. ; Vieira, F. V. ; Gameiro, R. ; Andrade, A. L. ; Eugenio, F. R. ; Flores, E. F. ; Cardoso, T. C.
Número total de Autores: 8
Tipo de documento: Artigo Científico
Fonte: VETERINARY AND COMPARATIVE ONCOLOGY; v. 15, n. 2, p. 336-344, JUN 2017.
Citações Web of Science: 7
Resumo

Oncolytic virotherapy is a novel strategy for treatment of cancer in humans and companion animals as well. Canine distemper virus (CDV), a paramyxovirus, has proven to be oncolytic through induction of apoptosis in canine-derived tumour cells, yet the mechanism behind this inhibitory action is poorly understood. In this study, three human mammary tumour cell lines and one canine-derived adenofibrosarcoma cell line were tested regarding to their susceptibility to CDV infection, cell proliferation, apoptosis, mitochondrial membrane potential and expression of tumour necrosis factor-alpha-induced protein 8 (TNFAIP8). CDV replication-induced cytopathic effect, decrease of cell proliferation rates, and >45% of infected cells were considered death and/or under late apoptosis/necrosis. TNFAIP8 and CDVM gene expression were positively correlated in all cell lines. In addition, mitochondrial membrane depolarization was associated with increase in virus titres (p<0.005). Thus, these results strongly suggest that both human and canine mammary tumour cells are potential candidates for studies concerning CDV-induced cancer therapy. (AU)

Processo FAPESP: 10/52465-9 - Isolamento e caracterização genética do reovirus de perus (TReoV) provenientes de quadros de enterite associados a PEMS (Poult Enteritis Mortality Syndrome) no Brasil
Beneficiário:Tereza Cristina Cardoso da Silva
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 11/50845-1 - Isolamento e caracterização genética do reovírus de Peru de amostras clínicas provenientes de quadro de entrerite associados a PEMS no Brasil
Beneficiário:Ana Carolina Guedes Rosa
Linha de fomento: Bolsas no Brasil - Doutorado