Rosemary supplementation (Rosmarinus oficinallis L.) attenuates cardiac remodeling after myocardial infarction in rats

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Murino Rafacho, Bruna Paola ; dos Santos, Priscila Portugal ; Goncalves, Andrea de Freitas ; Henrique Fernandes, Ana Angelica ; Okoshi, Katashi ; Chiuso-Minicucci, Fernanda ; Azevedo, Paula S. ; Mamede Zornoff, Leonardo Antonio ; Minicucci, Marcos Ferreira ; Wang, Xiang-Dong ; Rupp de Paiva, Sergio Alberto

• Tipo de documento: Artigo Científico
• Fonte: PLoS One; v. 12, n. 5 MAY 11 2017.
• Citações Web of Science: 4

Resumo

Background Myocardial infarction (MI) is one of the leading causes of morbidity and mortality worldwide. Dietary intervention on adverse cardiac remodeling after MI has significant clinical relevance. Rosemary leaves are a natural product with antioxidant/anti-inflammatory properties, but its effect on morphology and ventricular function after MI is unknown. Methods and results To determine the effect of the dietary supplementation of rosemary leaves on cardiac remodeling after MI, male Wistar rats were divided into 6 groups after sham procedure or experimental induced MI: 1) Sham group fed standard chow (SR0, n = 23); 2) Sham group fed standard chow supplemented with 0.02% rosemary (R002) (SR002, n = 23); 3) Sham group fed standard chow supplemented with 0.2% rosemary (R02) (SR02, n = 22); 4) group submitted to MI and fed standard chow (IR0, n = 13); 5) group submitted to MI and fed standard chow supplemented with R002 (IR002, n = 8); and 6) group submitted to MI and fed standard chow supplemented with R02 (IR02, n = 9). After 3 months of the treatment, systolic pressure evaluation, echocardiography and euthanasia were performed. Left ventricular samples were evaluated for: fibrosis, cytokine levels, apoptosis, energy metabolism enzymes, and oxidative stress. Rosemary dietary supplementation attenuated cardiac remodeling by improving energy metabolism and decreasing oxidative stress. Rosemary supplementation of 0.02% improved diastolic function and reduced hypertrophy after MI. Regarding rosemary dose, 0.02% and 0.2% for rats are equivalent to 11 mg and 110 mg for humans, respectively. Conclusion Our findings support further investigations of the rosemary use as adjuvant therapy in adverse cardiac remodeling. (AU)

• Processo FAPESP: 11/15059-5 - Influência da suplementação de alecrim (Rosmarinus oficinalis L.) na ração sobre remodelação cardíaca em ratos submetidos a infarto agudo do miocárdio
• Beneficiário: Sergio Alberto Rupp de Paiva
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 11/08956-0 - Influência da suplementação de alecrim (Rosmarinus oficinalis L.) na dieta sobre remodelação cardíaca em ratos submetidos a infarto agudo do miocárdio
• Beneficiário: Bruna Paola Murino Rafacho
• Modalidade de apoio: Bolsas no Brasil - Doutorado