Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Structural isomerism of Ru(II)-carbonyl complexes: synthesis, characterization and their antitrypanosomal activities

Texto completo
Autor(es):
Mostrar menos -
Barbosa, M. I. F. ; Correa, R. S. ; Bastos, T. M. ; Pozzi, L. V. ; Moreira, D. R. M. ; Ellena, J. ; Doriguetto, A. C. ; Silveira, R. G. ; Oliveira, C. R. ; Kuznetsov, A. E. ; Malta, V. S. ; Soares, M. B. P. ; Batista, A. A.
Número total de Autores: 13
Tipo de documento: Artigo Científico
Fonte: NEW JOURNAL OF CHEMISTRY; v. 41, n. 11, p. 4468-4477, JUN 7 2017.
Citações Web of Science: 6
Resumo

New complexes with the general formula {[}RuCl(CO)(dppb)(diimine)]PF6, {[}dppb = 1,4-bis(diphenylphosphino)butane; diimine = 2,2'-bipyridine (bipy) or 1,10-phenanthroline (phen)], were prepared. Thus, the complexes ct-{[}RuCl(CO)(dppb)(bipy)]PF6 (1), ct-{[}RuCl(CO)(dppb)(phen)]PF6 (2), tc-{[}RuCl(CO)(dppb)(bipy)]PF6 (3), tc-{[}RuCl(CO)(dppb)(phen)]PF6 (4), cc-{[}RuCl(CO)(dppb)(bipy)]PF6 (5) and cc-{[}RuCl(CO)(dppb)(phen)]PF6 (6) were obtained and characterized. In this case, the first letter in the prefixes indicates the position of CO with respect to the chlorido ligand and the second one is related to the phosphorus atoms. The compositions of the complexes were confirmed by analytical techniques and an octahedral environment around the ruthenium was confirmed by single-crystal X-ray diffraction of the complexes ct-{[}RuCl(CO)(dppb)(bipy)]PF6 and cc-{[}RuCl(CO)(dppb)(phen)]PF6. The oxidation potentials of the complexes were determined by cyclic voltammetry and it was found that they vary according to the CO position in the complexes. In order to obtain information on the stability of the ct, tc and cc-{[}RuCl(CO)(dppb)(bipy)]PF6 (1), (3) and (5) isomers, computational studies were carried out, and they showed large differences between the HOMO/LUMO energies. As monitored by C-13 NMR, the stability of the complexes with respect to CO displacement, for at least 72 h, in DMSO-d(6) solution, is independent of the CO position in the complexes. Pharmacological evaluation of the complexes against the Trypanosoma cruzi parasite revealed the structure-activity relationships, showing that the presence and position of the CO ligand in the complexes are relevant for the antiparasitic activity of the compounds. The most active compound, the tc-{[}RuCl(CO)(dppb)(bipy)]PF6 isomer, presented potent antiparasitic activity, which was achieved by causing oxidative stress followed by parasite cell death through necrosis. Thus, the findings presented here demonstrate that the use of a carbonyl ligand provides stability and pharmacological properties to ruthenium/diphosphine/diimine complexes. (AU)

Processo FAPESP: 14/10516-7 - Busca por complexos de rutênio (II), com propriedades quimioterapêuticas: avaliação de possíveis efeitos sinergísticos e possíveis mecanismo de ação
Beneficiário:Alzir Azevedo Batista
Linha de fomento: Auxílio à Pesquisa - Regular