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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Molecular and Genetic Aspects of Congenital Isolated Hypogonadotropic Hypogonadism

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Autor(es):
Lima Amato, Lorena Guimaraes ; Latronico, Ana Claudia ; Gontijo Silveira, Leticia Ferreira
Número total de Autores: 3
Tipo de documento: Artigo Científico
Fonte: ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA; v. 46, n. 2, p. 283+, JUN 2017.
Citações Web of Science: 4
Resumo

Congenital isolated hypogonadotropic hypogonadism (IHH) is a clinically and genetically heterogenous disorder characterized by abnormal synthesis, secretion, or action of gonadotropin-releasing hormone, a key hypothalamic decapeptide that orchestrates the reproductive axis. Several modes of inheritance have been identified. A growing list of causative genes has been implicated in the molecular pathogenesis of syndromic and nonsyndromic IHH, largely contributing for better understanding the complex neuroendocrine control of reproduction. This article summarizes the great advances of molecular genetics of IHH and pointed up the heterogeneity and complexity of the genetic basis of this condition. (AU)

Processo FAPESP: 13/03236-5 - Novas abordagens e metodologias na investigação genético-molecular dos distúrbios de crescimento e desenvolvimento puberal
Beneficiário:Alexander Augusto de Lima Jorge
Linha de fomento: Auxílio à Pesquisa - Temático