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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Palladium(II)/N,N-disubstituted-N `-acylthioureas complexes as anti-Mycobacterium tuberculosis and anti-Trypanosoma cruzi agents

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Plutin, Ana M. ; Alvarez, Anislay ; Mocelo, Raul ; Ramos, Raul ; Castellano, Eduardo E. ; da Silva, Monize M. ; Villarreal, Wilmer ; Pavan, Fernando R. ; Meira, Cassio Santana ; Rodrigues Filho, Jose Simao ; Moreira, Diogo Rodrigo M. ; Soares, Milena Botelho P. ; Batista, Alzir A.
Número total de Autores: 13
Tipo de documento: Artigo Científico
Fonte: Polyhedron; v. 132, p. 70-77, AUG 16 2017.
Citações Web of Science: 6
Resumo

The new complexes of Pd(II) with N,N-disubstituted-N'-acylthioureas:{[}(1) {[}Pd(dppf)(N,N-dimethyl-N'benzoylthioureato-k(2)O,S)]PF6, (2) {[}Pd(dppf)(N,N-diethyl-N'-benzoylthioureato-k(2)O,S)]PF6, (3) {[}Pd(dppf) (N,N-dibuthyl-N'-benzoylthioureato-k(2)O,S)]PE6, (4) {[}Pd(dPPO(N,N-diphenyl-N'-benzoylthioureato-k(2)O, S)]PF6, (5) {[}Pd(dppf)(N,N-diethyl-N'-furoylthioureato-k(2)O,S)]PF6, (6) {[}Pd(dppf)(N,N-diphenyl-N'-furoylthioureato-k(2)O,S)]PF6, (7) {[}Pd(dppf)(N,N-dimethyl-N'-thiophenylthioureato-k(2)O,S)]PF6, and (8) {[}Pd(dppf) (N,N-diphenyl-N'-thiophenylthioureato-k(2)O,S)]PF6, were prepared and characterized by elemental analysis, and spectroscopic techniques. The structures of complexes (2), (3), (5), (6) and (8) had their structures determined by X-ray crystallography, confirming the coordination of the ligands with the metal through sulfur and oxygen atoms, forming distorted square-planar geometries. These complexes have shown antibacterial activity against anti-Mycobacterium tuberculosis H37Rv ATCC 27294. The complexes exhibited antiparasitic activity against Trypanosoma cruzi, while the metal-free thioureas did not. The. results demonstrated that the compounds described here can be considered as promising anti Mycobacterium tuberculosis and anti-T. cruzi agents, since in both cases their in vitro activity were better than reference drugs available for the treatment of both diseases. (C) 2017 Elsevier Ltd. All rights reserved. (AU)

Processo FAPESP: 14/13691-4 - A cristalografia como ferramenta no auxílio para a elucidação do mecanismo de ação de potenciais metalofármacos
Beneficiário:Eduardo Ernesto Castellano
Linha de fomento: Auxílio à Pesquisa - Regular