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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Unconventional Secretion of Heat Shock Proteins in Cancer

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Autor(es):
Santos, Tiago Goss ; Martins, Vilma Regina ; Maroso Hajj, Glaucia Noeli
Número total de Autores: 3
Tipo de documento: Artigo de Revisão
Fonte: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 18, n. 5 MAY 2017.
Citações Web of Science: 18
Resumo

Heat shock proteins (HSPs) are abundant cellular proteins involved with protein homeostasis. They have both constitutive and inducible isoforms, whose expression levels are further increased by stress conditions, such as temperature elevation, reduced oxygen levels, infection, inflammation and exposure to toxic substances. In these situations, HSPs exert a pivotal role in offering protection, preventing cell death and promoting cell recovery. Although the majority of HSPs functions are exerted in the cytoplasm and organelles, several lines of evidence reveal that HSPs are able to induce cell responses in the extracellular milieu. HSPs do not possess secretion signal peptides, and their secretion was subject to widespread skepticism until the demonstration of the role of unconventional secretion forms such as exosomes. Secretion of HSPs may confer immune system modulation and be a cell-to-cell mediated form of increasing stress resistance. Thus, there is a wide potential for secreted HSPs in resistance of cancer therapy and in the development new therapeutic strategies. (AU)

Processo FAPESP: 15/02098-3 - Papel da stress inducible protein 1 (STI1) no desenvolvimento vascular embrionário e na angiogênese tumoral
Beneficiário:Tiago Góss dos Santos
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 09/14027-2 - Mecanismos associados à função da proteína prion e seu ligante STI1/Hop: abordagens terapêuticas
Beneficiário:Vilma Regina Martins
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 14/15550-9 - Controle traducional no câncer
Beneficiário:Glaucia Noeli Maroso Hajj
Linha de fomento: Auxílio à Pesquisa - Regular