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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

[10]-Gingerol Reverts Malignant Phenotype of Breast Cancer Cells in 3D Culture

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Autor(es):
Fuzer, Angelina M. ; Lee, Sun-Young ; Mott, Joni D. ; Cominetti, Marcia R.
Número total de Autores: 4
Tipo de documento: Artigo Científico
Fonte: Journal of Cellular Biochemistry; v. 118, n. 9, p. 2693-2699, SEP 2017.
Citações Web of Science: 6
Resumo

Breast cancer is a complex and multifactorial disease. Tumors have a heterogeneous microenvironment, which have multiple interactions with other cell types, greatly influencing the behavior of tumor cells and response to therapy. The 3D culture mimics the microenvironment better found in vivo and is more appropriated than the traditional 2D culture made from plastic to test the cellular response to drugs. To investigate the effects of {[}10]-gingerol on breast tumor cells, we used physiologically relevant three-dimensional (3D) cultures of malignant and non-malignant human breast cells grown in laminin-rich extracellular matrix gels (lr-ECM). Our results showed selective cytotoxicity of {[}10]-gingerol against the malignant T4-2 breast cancer cell line compared to non-malignant S1 cells. The compound reverted the malignant phenotype of the cancer cells, downregulating the expression of epidermal growth factor receptor (EGFR) and 1-integrin. Moreover, {[}10]-gingerol induced apoptosis in this cell line. These results suggest that {[}10]-gingerol may be an effective compound to use as adjuvant therapy in breast cancer treatment. (C) 2017 Wiley Periodicals, Inc. (AU)

Processo FAPESP: 15/08146-0 - Efeitos do [10]-gingerol no microambiente tumoral tridimensional
Beneficiário:Angelina Maria Fuzer
Linha de fomento: Bolsas no Exterior - Estágio de Pesquisa - Doutorado Direto
Processo FAPESP: 13/00798-2 - A matriz extracelular no envelhecimento, no exercício e no microambiente tumoral
Beneficiário:Heloisa Sobreiro Selistre de Araújo
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 12/18908-6 - Mecanismos celulares e moleculares envolvidos na ação antiproliferativa do [10]-gingerol sobre células de tumor de mama
Beneficiário:Angelina Maria Fuzer
Linha de fomento: Bolsas no Brasil - Doutorado Direto