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Distribution of HBV subgenotypes in Ribeirao Preto, Southeastern Brazil: a region with history of intense Italian immigration

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Autor(es):
Florencio Chacha, Silvana Gama ; Gomes-Gouvea, Michele Soares ; Malta, Fernanda de Mello ; Ferreira, Sandro da Costa ; Villanova, Marcia Guimaraes ; Souza, Fernanda Fernandes ; Teixeira, Andreza Correa ; da Costa Passosd, Afonso Dinis ; Rebello Pinho, Joao Renato ; Candolo Martinelli, Ana de Lourdes
Número total de Autores: 10
Tipo de documento: Artigo Científico
Fonte: Brazilian Journal of Infectious Diseases; v. 21, n. 4, p. 424-432, JUL-AUG 2017.
Citações Web of Science: 4
Resumo

Hepatitis B virus (HBV) is distributed worldwide, with geographical variations regarding prevalence of the different genotypes. The aim of this study was to determine the HBV genotypes and subgenotypes circulating in Southeast Brazil and compare the genetic sequences found with HBV sequences previously described in the world. Sequences from 166 chronic HBV carriers were analyzed using the fragment constituted by 1306 base pairs comprising surface and polymerase regions of the HBV genome. The sequences obtained were submitted to phylogenetic analysis. HBV subgenotypes A1, A2, D1-D4, F2a, and F4 were found. HBV genotype D was the most frequent, found in 99 patients (58.4%). Within this group, subgenotype D3 was the most prevalent, in 73 patients (42.9%). HBV genotype A was identified in 58 (36%) patients, subgenotype Al, in 48 (29.8%) subjects. Genotype F was identified in 9 (5.4%). According to the phylogenetic analysis, the sequences found were grouped with sequences from Europe, Asia and Middle East (subgenotypes D1, D2, D3) and sequences from Latin America and Africa (subgenotype Al). HBV D3 grouped in different clusters inside D3 Glade, several of them with sequences isolated in Italy. We also identified eight families whose relatives were infected with the same HBV subgenotype, most with high similarity between sequences. In conclusion, the distribution of the HBV sequences obtained interweaved with sequences from other continents, corresponding to regions from where many immigrants came to this region, in accordance to the hypothesis that the HBV detected over there were brought during the colonization times. (C) 2017 Sociedade Brasileira de Infectologia. Published by Elsevier Editora Ltda. (AU)

Processo FAPESP: 08/11472-2 - Estudo do papel dos genótipos do vírus da hepatite B (HBV) na gravidade da doença hepática, na evolução clínica e na resposta ao tratamento antiviral na infecção crônica pelo HBV
Beneficiário:Ana de Lourdes Candolo Martinelli
Linha de fomento: Auxílio à Pesquisa - Regular