Biocatalytic aminolysis of ethyl (S)-mandelate by lipase from Candida antarctica

Autor(es)

Lima, Rafaely N. ; Porto, Andre L. M.

• Tipo de documento: Artigo Científico
• Fonte: Catalysis Communications; v. 100, p. 157-163, SEP 2017.
• Citações Web of Science: 5

Resumo

Enzymes play many roles in the advancement of biotechnology, discovery of new therapeutic agents and industrial processes. In this perspective, aminolysis reactions using lipase from Candida antarctica (CAL-B) were performed from ethyl (S)-mandelate and several aliphatic amines (45 degrees C, hexane, 3-6 h). By means of optimized conditions, amides with excellent isolated yields (60-97%) were synthetized. The biotechnological potential of CAL-B as a promising approach for the synthesis of organic compounds in a more sustainable, rapid, efficient and green chemistry perspective was verified on these results. (AU)

• Processo FAPESP: 14/18257-0 - Novas abordagens em reações biocatalíticas
• Beneficiário: Andre Luiz Meleiro Porto
• Modalidade de apoio: Auxílio à Pesquisa - Regular