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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Albuminuria, renal function and blood pressure in undernourished children and recovered from undernutrition

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Autor(es):
Martins, Vinicius J. B. ; Sesso, Ricardo ; Clemente, Ana P. G. ; Fernandes, Mariana B. F. ; Sawaya, Ana L.
Número total de Autores: 5
Tipo de documento: Artigo Científico
Fonte: Pediatric Nephrology; v. 32, n. 9, p. 1555-1563, SEP 2017.
Citações Web of Science: 1
Resumo

Background The objective of this study was to investigate some biomarkers of renal function and blood pressure in children who had recovered from undernutrition. Methods This was cross-sectional, comparative study in which a convenience sample of children of both genders (n = 126; age range 6-16 years) treated at the Centre for Nutritional Recovery and Education (Sao Paulo, Brazil) was used. These children were classified into four groups for analysis: (1) children who were well nourished (control group; n = 50), (2) those showing stunted growth (stunted group; n = 22), (3) those who were underweight (underweight group; n = 23) and (4) those who had recovered from undernutrition (recovered group; n = 31). Results No between-group differences were found for mean levels of albuminuria, serum creatinine and cystatin C, and similar mean estimates of glomerular filtration rate (eGFR; using either creatinine, cystatin C or both). Almost 14% of the stunted group, 4% of the underweight group and 3% of the recovered group had albuminuria of >30 mg/g creatinine chi-square p = 0.034); none of the control children showed albuminuria of >30 mg/g creatinine. Mean systolic (SBP) and diastolic blood pressure (DBP) adjusted for age and gender of the children in the stunted {[} SBP (95% confidence interval): 92 (88-96) mmHg; DBP: 47 (44-49) mmHg] and recovered {[} SBP: 93 (90-96) mmHg; DBP: 49 (47-51) mmHg] groups were significantly lower than those of the controls {[} SBP: 98 (95-100) mmHg, P = 0.027; DBP: 53 (5255) mmHg, P = 0.001]. After additional adjustment for height, mean DBP remained significantly lower in the recovered group compared with the control group {[} 49 (46-51) vs. 53 (51-55) mmHg, respectively; P = 0.018). Logistic regression analysis showed that the stunted group had a 8.4-fold higher chance of developing albuminuria (>10 mg/g creatinine) than the control children (P = 0.006). Conclusions No alterations in renal function were found in underweight children and those who had recovered from undernutrition, whereas children with stunted growth presented with a greater risk for albuminuria. A lower DBP was found in children with stunted growth and those who had recovered from undernutrition. (AU)

Processo FAPESP: 10/51237-2 - Efeitos da recuperação nutricional no controle do estresse, na pressão arterial e na função renal
Beneficiário:Ana Lydia Sawaya
Linha de fomento: Auxílio à Pesquisa - Regular