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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Corticosterone influences gerbil (Meriones unguiculatus) prostatic morphophysiology and alters its proliferation and apoptosis rates

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Autor(es):
Antoniassi, Julia Quilles ; Fochi, Ricardo Alexandre ; Goes, Rejane Maira ; Leite Vilamaior, Patricia Simone ; Taboga, Sebastiao Roberto
Número total de Autores: 5
Tipo de documento: Artigo Científico
Fonte: International Journal of Experimental Pathology; v. 98, n. 3, p. 134-146, JUN 2017.
Citações Web of Science: 1
Resumo

Glucocorticoids (GCs) are hormones that are widely used in medicine; but although side effects are generally recognised, little is known about the precise mechanisms that is implicated in many of these side effects. Furthermore, GCs are highly correlated with stress and behaviour disorders. This study evaluated the effects of the glucocorticoid corticosterone on the ventral prostate of the Mongolian gerbil. Male gerbils (Meriones unguiculatus) (n = 5) received intraperitoneal injections of saline or corticosterone in doses of 0.5 mg/kg/day and 1.5 mg/kg/day for 5 days; while some of the animals were killed immediately after the treatment, the others were killed 5 days after the treatment period. The data show that corticosterone influences the structure and functionality of this organ. This hormone has anti-proliferative and anti-apoptotic properties in the prostate. In addition, the frequencies of the androgen (AR), oestrogen (ER alpha, ER beta) and glucocorticoid (GR) receptors changed. The frequencies of AR, GR and ER beta decreased in the Ct1/5 group; in the groups with rest period, the frequencies of GR increased and ER beta decreased in the epithelium. Changes in the proliferative index, apoptotic index and receptor activity may have contributed to the emergence of prostatic morphological alterations, such as the presence of cellular debris and inflammatory cells. Different doses of corticosterone had variable effects on the prostate, with a higher dose showing subtler effects and a lower dose showing more striking effects. The corticosterone effects on nuclear receptors were reverted or attenuated after a rest period, which was not observed for proliferation and apoptosis. In summary, we have demonstrated that corticosterone might influence the prostatic morphophysiology and that these changes may be linked in some way to the altered receptor distribution. (AU)

Processo FAPESP: 11/06335-9 - Efeitos da exposição intra-uterina e puberal a desreguladores endócrinos sobre a próstata de Gerbilos senis
Beneficiário:Sebastião Roberto Taboga
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 09/16790-5 - Avaliação da próstata de gerbilos senis, machos e fêmeas, expostos ao etinilestradiol durante o período pré-natal e puberal
Beneficiário:Ana Paula da Silva Perez
Linha de fomento: Bolsas no Brasil - Doutorado