Biomass burning in the Amazon region causes DNA damage and cell death in human lung cells

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Alves, Nilmara de Oliveira ; Vessoni, Alexandre Teixeira ; Quinet, Annabel ; Fortunato, Rodrigo Soares ; Kajitani, Gustavo Satoru ; Peixoto, Milena Simoes ; Hacon, Sandra de Souza ; Artaxo, Paulo ; Saldiva, Paulo ; Martins Menck, Carlos Frederico ; Batistuzzo de Medeiros, Silvia Regina

• Tipo de documento: Artigo Científico
• Fonte: SCIENTIFIC REPORTS; v. 7, SEP 7 2017.
• Citações Web of Science: 9

Resumo

Most of the studies on air pollution focus on emissions from fossil fuel burning in urban centers. However, approximately half of the world's population is exposed to air pollution caused by biomass burning emissions. In the Brazilian Amazon population, over 10 million people are directly exposed to high levels of pollutants resulting from deforestation and agricultural fires. This work is the first study to present an integrated view of the effects of inhalable particles present in emissions of biomass burning. Exposing human lung cells to particulate matter smaller than 10 mu m (PM10), significantly increased the level of reactive oxygen species (ROS), inflammatory cytokines, autophagy, and DNA damage. Continued PM10 exposure activated apoptosis and necrosis. Interestingly, retene, a polycyclic aromatic hydrocarbon present in PM10, is a potential compound for the effects of PM10, causing DNA damage and cell death. The PM10 concentrations observed during Amazon biomass burning were sufficient to induce severe adverse effects in human lung cells. Our study provides new data that will help elucidate the mechanism of PM10-mediated lung cancer development. In addition, the results of this study support the establishment of new guidelines for human health protection in regions strongly impacted by biomass burning. (AU)

• Processo FAPESP: 14/15982-6 - Consequências de deficiências de reparo de lesões no genoma
• Beneficiário: Carlos Frederico Martins Menck
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 14/02297-3 - O reparo por excisão de nucleotídeo está envolvido no mecanismo de ação dos poluentes atmosféricos urbano?
• Beneficiário: Nilmara de Oliveira Alves Brito
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 13/05014-0 - GoAmazon: interação da pluma urbana de Manaus com emissões biogênicas da Floresta Amazônica
• Beneficiário: Paulo Eduardo Artaxo Netto
• Modalidade de apoio: Auxílio à Pesquisa - Programa de Pesquisa sobre Mudanças Climáticas Globais - Temático