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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Circulating leptin and its muscle gene expression in Nellore cattle with divergent feed efficiency

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Macedo Mota, Lucio Flavio ; Bonafe, Cristina Moreira ; Alexandre, Pamela Almeida ; Santana, Miguel Henrique ; Novais, Francisco Jose ; Toriyama, Erika ; Pires, Aldrin Vieira ; Silva, Saulo da Luz ; Leme, Paulo Roberto ; Sterman Ferraz, Jose Bento ; Fukumasu, Heidge
Número total de Autores: 11
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY; v. 8, SEP 1 2017.
Citações Web of Science: 2
Resumo

Background: Leptin has a strong relation to important traits in animal production, such as carcass composition, feed intake, and reproduction. It is mainly produced by adipose cells and acts predominantly in the hypothalamus. In this study, circulating leptin and its gene expression in muscle were evaluated in two groups of young Nellore bulls with divergent feed efficiency. Individual dry matter intake (DMI) and average daily gain (ADG) of 98 Nellore bulls were evaluated in feedlot for 70 d to determinate the residual feed intake (RFI) and select 20 animals for the high feed efficient (LRFI) and 20 for the low feed efficient (HRFI) groups. Blood samples were collected on d 56 and at slaughter (80 d) to determine circulating plasma leptin. Samples of Longissimus dorsi were taken at slaughter for leptin gene expression levels. Results: DMI and RFI were different between groups and LRFI animals showed less back fat and rump fat thickness, as well as less pelvic and kidney fat weight. Circulating leptin increased over time in all animals. Plasma leptin was greater in LRFI on 56 d and at slaughter (P = 0.0049). Gene expression of leptin were greater in LRFI animals (P = 0. 0022) in accordance with the plasma levels. The animals of the LRFI group were leaner, ate less, and had more circulating leptin and its gene expression. Conclusion: These findings demonstrated that leptin plays its physiological role in young Nellore bulls, probably controlling food intake because feed efficient animals have more leptin and lower residual feed intake. (AU)

Processo FAPESP: 10/05650-5 - Avaliação nutrigenética do receptor androstano constitutivo (CAR, NR1i3) sobre a eficiência alimentar em bovinos da raça Nelore
Beneficiário:Heidge Fukumasu
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 14/07566-2 - Genômica aplicada à produção de ruminantes
Beneficiário:José Bento Sterman Ferraz
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 14/02493-7 - Neoplasias mamárias de cadelas e a teoria das células-tronco cancerosas: uma abordagem comparada e translacional
Beneficiário:Heidge Fukumasu
Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores