| Texto completo | |
| Autor(es): |
Gargaglioni, Luciane H.
;
Coimbra, Norberto C.
[2]
;
Branco, Luiz G. S.
Número total de Autores: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Neuroscience Letters; v. 347, n. 2, p. 121-125, Aug. 2004. |
| Área do conhecimento: | Ciências Biológicas - Fisiologia |
| Assunto(s): | Sistema nervoso central Hipotermia |
| Resumo | |
The nucleus raphe magnus (NRM) is one of the brainstem cell groups involved in physiological responses to hypoxia. Thus, we tested the hypothesis that the NRM modulates hypoxia-induced hyperventilation and anapyrexia. To this end, we assessed the participation of NRM in the respiratory and thermoregulatory responses to hypoxia using ibotenic acid lesions produced in the NRM of rats. Our results demonstrated that, under resting breathing, NRM plays no role in ventilation or body temperature. Hypoxia caused hyperventilation and anapyrexia in all groups. NMR lesions elicited an increased ventilatory response to hypoxia due to a higher tidal volume (VT) but did not affect hypoxia-induced anapyrexia. Therefore, we conclude that NRM exerts an inhibitory modulation of breathing during hypoxia, acting on VT, but plays no role in the hypoxia-induced anapyrexia. (AU) | |
| Processo FAPESP: | 02/01497-1 - Estudo do envolvimento do núcleo magno da rafe, do núcleo gigantocelular e núcleo pré-tectal anterior, e de receptores opiódes, kappa e delta serotoninérgicos 5HT2/1C, e noradrenérgicos alfa, beta, na analgesia pós-cital: um estudo neuroanatômico e neuropsicofisiológico em um modelo experimental de epilepsia |
| Beneficiário: | Daoud Hibrahim Elias Filho |
| Modalidade de apoio: | Bolsas no Brasil - Programa Capacitação - Treinamento Técnico |