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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

[10]-gingerol induces apoptosis and inhibits metastatic dissemination of triple negative breast cancer in vivo

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Autor(es):
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Martin, Ana Carolina B. M. [1] ; Fuzer, Angelina M. [1] ; Becceneri, Amanda B. [1] ; da Silva, James Almada [2] ; Tomasin, Rebeka [1] ; Denoyer, Delphine [3] ; Kim, Soo-Hyun [4, 5] ; McIntyre, Katherine A. [6] ; Pearson, Helen B. [7] ; Yeo, Belinda [8] ; Nagpal, Aadya [8] ; Ling, Xiawei [4, 5] ; Selistre-de-Araujo, Heloisa S. [9] ; Vieira, Paulo Cezar [2] ; Cominetti, Marcia R. [1] ; Pouliot, Normand [4, 6, 8, 5]
Número total de Autores: 16
Afiliação do(s) autor(es):
[1] Univ Fed Sao Carlos, Dept Gerontol, Sao Carlos, SP - Brazil
[2] Univ Fed Sao Carlos, Dept Chem, Sao Carlos, SP - Brazil
[3] Deakin Univ, Met Med Lab, CCMB, Melbourne Burwood Campus, Geelong, Vic 3217 - Australia
[4] Univ Melbourne, Melbourne, Vic 3010 - Australia
[5] Dept Pathol, Melbourne, Vic - Australia
[6] Univ Melbourne, Sir Peter MacCallum Dept Oncol, Melbourne, Vic 3010 - Australia
[7] Cardiff Univ, European Canc Stem Cell Res Inst, Cardiff, S Glam - Wales
[8] La Trobe Univ, Matrix Microenvironm & Metastasis Lab, Olivia Newton John Canc Res Inst Sch, Sch Canc Med, Heidelberg, Vic - Australia
[9] Univ Fed Sao Carlos, Dept Physiol Sci, Sao Carlos, SP - Brazil
Número total de Afiliações: 9
Tipo de documento: Artigo Científico
Fonte: ONCOTARGET; v. 8, n. 42, p. 72260-72271, SEP 22 2017.
Citações Web of Science: 10
Resumo

There is increasing interest in the use of non-toxic natural products for the treatment of various pathologies, including cancer. In particular, biologically active constituents of the ginger oleoresin (Zingiber officinale Roscoe) have been shown to mediate anti-tumour activity and to contribute to the anti-inflammatory, antioxidant, antimicrobial, and antiemetic properties of ginger. Here we report on the inhibitory properties of {[}10]-gingerol against metastatic triple negative breast cancer (TNBC) in vitro and in vivo. We show that {[}10]-gingerol concentration-dependently induces apoptotic death in mouse and human TNBC cell lines in vitro. In addition, {[}10]-gingerol is well tolerated in vivo, induces a marked increase in caspase-3 activation and inhibits orthotopic tumour growth in a syngeneic mouse model of spontaneous breast cancer metastasis. Importantly, using both spontaneous and experimental metastasis assays, we show for the first time that {[}10]-gingerol significantly inhibits metastasis to multiple organs including lung, bone and brain. Remarkably, inhibition of brain metastasis was observed even when treatment was initiated after surgical removal of the primary tumour. Taken together, these results indicate that {[}10]-gingerol may be a safe and useful complementary therapy for the treatment of metastatic breast cancer and warrant further investigation of its efficacy, either alone or in combination with standard systemic therapies, in pre-clinical models of metastatic breast cancer and in patients. (AU)

Processo FAPESP: 15/24940-8 - Avaliação da eficácia de mudanças estruturais do [10]-gingerol em combinação com o quimioterápico doxorubicina para o tratamento de câncer de mama: estudos in vitro e in vivo
Beneficiário:Márcia Regina Cominetti
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 12/03771-5 - Identificação de genes supressores de metástase
Beneficiário:Rebeka Tomasin
Linha de fomento: Bolsas no Exterior - Estágio de Pesquisa - Doutorado
Processo FAPESP: 13/00798-2 - A matriz extracelular no envelhecimento, no exercício e no microambiente tumoral
Beneficiário:Heloisa Sobreiro Selistre de Araújo
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 12/18908-6 - Mecanismos celulares e moleculares envolvidos na ação antiproliferativa do [10]-gingerol sobre células de tumor de mama
Beneficiário:Angelina Maria Fuzer
Linha de fomento: Bolsas no Brasil - Doutorado Direto