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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Insights from Systems Biology in Physiological Studies: Learning from Context

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Autor(es):
Imenez Silva, Pedro Henrique [1, 2] ; Melo, Diogo [3] ; Ribeiro de Mendonca, Pedro Omori [4, 5]
Número total de Autores: 3
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Inst Ciencias Biomed, Dept Fisiol & Biofis, Sao Paulo - Brazil
[2] Univ Zurich, Inst Physiol, Winterthurerstr 190, CH-8057 Zurich - Switzerland
[3] Univ Sao Paulo, Inst Biociencias, Dept Genet & Biol Evolut, Sao Paulo - Brazil
[4] Univ Sao Paulo, Inst Ciencias Biomed, Dept Anat, Sao Paulo - Brazil
[5] Hosp Israelita Albert Einstein, Sao Paulo - Brazil
Número total de Afiliações: 5
Tipo de documento: Artigo de Revisão
Fonte: CELLULAR PHYSIOLOGY AND BIOCHEMISTRY; v. 42, n. 3, p. 939-951, 2017.
Citações Web of Science: 1
Resumo

Systems biology presents an integrated view of biological systems, focusing on the relations between elements, whether functional or evolutionary, and providing a rich framework for the comprehension of life. At the same time, many low-throughput experimental studies are performed without influence from this integrated view, whilst high-throughput experiments use low-throughput results in their validation and interpretation. We propose an inversion in this logic, and ask which benefits could be obtained from a holistic view coming from high-throughput studies. and systems biology in particular. in interpreting and designing low-throughput experiments. By exploring some key examples from the renal and adrenal physiology, we try to show that network and modularity theory, along with observed patterns of association between elements in a biological system, can have profound effects on our ability to draw meaningful conclusions from experiments. (C) 2017 The Author(s) Published by S. Karger AG, Basel (AU)

Processo FAPESP: 12/23535-4 - O papel dos peptídeos derivados da POMC na diferenciação e função do córtex adrenal
Beneficiário:Pedro Omori Ribeiro de Mendonça
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 14/26262-4 - Estimativas diretas de parâmetros evolutivos via análise de loci de traços quantitativos
Beneficiário:Diogo Amaral Reboucas Melo
Linha de fomento: Bolsas no Brasil - Doutorado