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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Serum Metabolic Alterations upon Zika Infection

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Autor(es):
Melo, Carlos Fernando O. R. [1] ; Delafiori, Jeany [1] ; de Oliveira, Diogo N. [1] ; Guerreiro, Tatiane M. [1] ; Esteves, Cibele Z. [1] ; Lima, Estela de O. [1] ; Pando-Robles, Victoria [2] ; Catharino, Rodrigo R. [1] ; Network, Zika-Unicamp
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] Univ Estadual Campinas, Sch Pharmaceut Sci, INNOVARE Biomarkers Lab, Campinas, SP - Brazil
[2] Inst Nacl Salud Publ, Unidad Prote, Cuernavaca, Morelos - Mexico
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: FRONTIERS IN MICROBIOLOGY; v. 8, OCT 10 2017.
Citações Web of Science: 11
Resumo

Zika virus (ZIKV) infection has recently emerged as a major concern worldwide due to its strong association with nervous system malformation (microcephaly) of fetuses in pregnant women infected by the virus. Signs and symptoms of ZIKV infection are often mistaken with other common viral infections. Since transmission may occur through biological fluids exchange and coitus, in addition to mosquito bite, this condition is an important infectious disease. Thus, understanding the mechanism of viral infection has become an important research focus, as well as providing potential targets for assertive clinical diagnosis and quality screening for hemoderivatives. Within this context, the present work analyzed blood plasma from 79 subjects, divided as a control group and a ZIKV-infected group. Samples underwent direct-infusion mass spectrometry and statistical analysis, where eight markers related to the pathophysiological process of ZIKV infection were elected and characterized. Among these, Angiotensin (1-7) and Angiotensin I were upregulated under infection, showing an attempt to induce autophagy of the infected cells. However, this finding is concerning about hypertensive individuals under treatment with inhibitors of the Renin-Angiotensin System (RAS), which could reduce this response against the virus and exacerbate the symptoms of the infection. Moreover, one of the most abundant glycosphingolipids in the nervous tissue, Ganglioside GM2, was also elected in the present study as an infection biomarker. Considered an important pathogen receptor at membrane's outer layer, this finding represents the importance of gangliosides for ZIKV infection and its association with brain tropism. Furthermore, a series of phosphatidylinositols were also identified as biomarkers, implying a significant role of the PI3K-AKT-mTOR Pathway in this mechanism. Finally, these pathways may also be understood as potential targets to be considered in pharmacological intervention studies on ZIKV infection management. (AU)

Processo FAPESP: 16/17066-2 - Metabolômica e lipidômica do Zika vírus, do mosquito ao paciente
Beneficiário:Carlos Fernando Odir Rodrigues Melo
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 14/00302-0 - Shotgun lipidômico em giardíase, meningites e tuberculose: a busca de marcadores para diagnósticos, empregando novas e revolucionárias técnicas de espectrometria de massas
Beneficiário:Cibele Zanardi Esteves
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 15/06809-1 - Determinação de marcadores químicos em diferentes produtos bovinos por espectrometria de massas
Beneficiário:Rodrigo Ramos Catharino
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 11/50400-0 - Metabolismo energético, estado redox e funcionalidade mitocondrial na morte celular e em desordens cardiometabólicas e neurodegenerativas
Beneficiário:Aníbal Eugênio Vercesi
Linha de fomento: Auxílio à Pesquisa - Temático